(2-oxo-1,4-dihydro-2H-benzo[1,3]oxazin-8-yl)phosphonic acid benzyl ester ethyl ester

Base Information

Chemical Name:(2-oxo-1,4-dihydro-2H-benzo[1,3]oxazin-8-yl)phosphonic acid benzyl ester ethyl ester
CAS No.:316831-51-3
Molecular Formula:C₁₇H₁₈NO₅P
Molecular Weight:347.307
Hs Code.:

Synonyms:(2-oxo-1,4-dihydro-2H-benzo[1,3]oxazin-8-yl)phosphonic acid benzyl ester ethyl ester

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Chemical Property of (2-oxo-1,4-dihydro-2H-benzo[1,3]oxazin-8-yl)phosphonic acid benzyl ester ethyl ester

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Technology Process of (2-oxo-1,4-dihydro-2H-benzo[1,3]oxazin-8-yl)phosphonic acid benzyl ester ethyl ester

There total 3 articles about (2-oxo-1,4-dihydro-2H-benzo[1,3]oxazin-8-yl)phosphonic acid benzyl ester ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 6919-86-4
benzyl ethyl phosphonate

: 8-iodo-1,4-dihydrobenzo[1,3]oxazin-2-one

: 316831-51-3
(2-oxo-1,4-dihydro-2H-benzo[1,3]oxazin-8-yl)phosphonic acid benzyl ester ethyl ester

Guidance literature:: With triethylsilane; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; toluene; at 50 - 60 ℃; for 2h;
DOI:10.1021/ol0066330

Reference yield:

: 53279-84-8
(2-amino-3-iodophenyl)methanol

: 316831-51-3
(2-oxo-1,4-dihydro-2H-benzo[1,3]oxazin-8-yl)phosphonic acid benzyl ester ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / 60percent sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

2: 87 percent / triethylamine; triethylsilane / [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium (II) / toluene; CH₂Cl₂ / 2 h / 50 - 60 °C

With triethylsilane; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; dichloromethane; toluene; 1: Carbonylation / 2: Cross-coupling;
DOI:10.1021/ol0066330

Reference yield:

methyl 2-amino-3-iodobenzoate: methyl 2-amino-3-iodobenzoate

: 316831-51-3
(2-oxo-1,4-dihydro-2H-benzo[1,3]oxazin-8-yl)phosphonic acid benzyl ester ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / sodium borohydride; zinc chloride / tetrahydrofuran / 2 h / Heating

2: 75 percent / 60percent sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

3: 87 percent / triethylamine; triethylsilane / [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium (II) / toluene; CH₂Cl₂ / 2 h / 50 - 60 °C

With triethylsilane; sodium tetrahydroborate; triethylamine; zinc(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; dichloromethane; toluene; 1: Reduction / 2: Carbonylation / 3: Cross-coupling;
DOI:10.1021/ol0066330