di-tert-butyl (2-chloro-4-cyano-3-fluorophenyl)propanedioate

Base Information

• Chemical Name: di-tert-butyl (2-chloro-4-cyano-3-fluorophenyl)propanedioate
• CAS No.: 1428478-97-0
• Molecular Formula: C₁₈H₂₁ClFNO₄
• Molecular Weight: 369.82
• Mol file: 1428478-97-0.mol

Synonyms:di-tert-butyl (2-chloro-4-cyano-3-fluorophenyl)propanedioate

Chemical Property of di-tert-butyl (2-chloro-4-cyano-3-fluorophenyl)propanedioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-tert-butyl (2-chloro-4-cyano-3-fluorophenyl)propanedioate

There total 2 articles about di-tert-butyl (2-chloro-4-cyano-3-fluorophenyl)propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-2,4-difluorobenzonitrile (887267-38-1) + di-tert-butyl dicarbonate (24424-99-5) → di-tert-butyl (2-chloro-4-cyano-3-fluorophenyl)propanedioate (1428478-97-0)

Guidance literature:

di-tert-butyl dicarbonate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

3-chloro-2,4-difluorobenzonitrile; In N,N-dimethyl-formamide; mineral oil; at 0 - 80 ℃; for 12h;

Reference yield:

3-chloro-2,4-difluorobenzonitrile (887267-38-1) + t-butyl malonate (541-16-2) → di-tert-butyl (2-chloro-4-cyano-3-fluorophenyl)propanedioate (1428478-97-0)

Guidance literature:

t-butyl malonate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

3-chloro-2,4-difluorobenzonitrile; In N,N-dimethyl-formamide; at 0 - 80 ℃; for 12h;

Reference yield:

di-tert-butyl (2-chloro-4-cyano-3-fluorophenyl)propanedioate (1428478-97-0) → (2-chloro-4-cyano-3-fluorophenyl)acetic acid (1428478-96-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

upstream raw materials:

3-chloro-2,4-difluorobenzonitrile

di-tert-butyl dicarbonate

t-butyl malonate

Downstream raw materials:

(2-chloro-4-cyano-3-fluorophenyl)acetic acid