(R)-N-6-(2,5-dimethyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-N-4-(2-(isopropylsulfonyl)phenyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

Base Information

Chemical Name:(R)-N-6-(2,5-dimethyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-N-4-(2-(isopropylsulfonyl)phenyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
CAS No.:1609171-53-0
Molecular Formula:C₃₀H₃₇N₇O₃S
Molecular Weight:575.735
Hs Code.:

(R)-N-6-(2,5-dimethyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-N-4-(2-(isopropylsulfonyl)phenyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

Synonyms:(R)-N-6-(2,5-dimethyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-N-4-(2-(isopropylsulfonyl)phenyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

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Chemical Property of (R)-N-6-(2,5-dimethyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-N-4-(2-(isopropylsulfonyl)phenyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

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Technology Process of (R)-N-6-(2,5-dimethyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-N-4-(2-(isopropylsulfonyl)phenyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

There total 14 articles about (R)-N-6-(2,5-dimethyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-N-4-(2-(isopropylsulfonyl)phenyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609171-12-1
N-(2-(isopropylsulfonyl)phenyl)-3-methyl-6-(methylsulfonyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

: 1609171-21-2
(R)-2,5-dimethyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-amine

: 1609171-53-0
(R)-N-6-(2,5-dimethyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-N-4-(2-(isopropylsulfonyl)phenyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

Guidance literature:: With toluene-4-sulfonic acid; In isopropyl alcohol; at 160 ℃; for 5h; Sealed tube;

Reference yield:

: 1609171-19-8
(R)-4-bromo-2,5-dimethyl-2,3-dihydrobenzofuran-7-amine

: 1609171-53-0
(R)-N-6-(2,5-dimethyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-N-4-(2-(isopropylsulfonyl)phenyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 1 h / 135 °C / Inert atmosphere

2: triethylamine; hydrogen; platinum(IV) oxide; acetic acid / 24 h / 20 °C / 4551.02 Torr

3: toluene-4-sulfonic acid / isopropyl alcohol / 5 h / 160 °C / Sealed tube

With platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; caesium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; In water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1609171-20-1
(R)-2,5-dimethyl-4-(pyridin-4-yl)-2,3-dihydrobenzofuran-7-amine

: 1609171-53-0
(R)-N-6-(2,5-dimethyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-N-4-(2-(isopropylsulfonyl)phenyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; hydrogen; platinum(IV) oxide; acetic acid / 24 h / 20 °C / 4551.02 Torr

2: toluene-4-sulfonic acid / isopropyl alcohol / 5 h / 160 °C / Sealed tube

With platinum(IV) oxide; hydrogen; toluene-4-sulfonic acid; acetic acid; triethylamine; In isopropyl alcohol;