(6-{4-[(2-Amino-4-oxo-1,4-dihydro-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-hexyl)-carbamic acid tert-butyl ester

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Chemical Name:(6-{4-[(2-Amino-4-oxo-1,4-dihydro-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-hexyl)-carbamic acid tert-butyl ester
CAS No.:718605-04-0
Molecular Formula:C₂₇H₃₃F₃N₈O₅
Molecular Weight:606.605
Hs Code.:

Synonyms:(6-{4-[(2-Amino-4-oxo-1,4-dihydro-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-hexyl)-carbamic acid tert-butyl ester

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Chemical Property of (6-{4-[(2-Amino-4-oxo-1,4-dihydro-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-hexyl)-carbamic acid tert-butyl ester

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Technology Process of (6-{4-[(2-Amino-4-oxo-1,4-dihydro-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-hexyl)-carbamic acid tert-butyl ester

There total 2 articles about (6-{4-[(2-Amino-4-oxo-1,4-dihydro-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-hexyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 51857-17-1
tert-butyl N-(6-aminohexyl)carbamate

: 37793-53-6
N¹⁰-(trifluoroacetyl)pteroic acid

: 718605-04-0
(6-{4-[(2-Amino-4-oxo-1,4-dihydro-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-hexyl)-carbamic acid tert-butyl ester

Guidance literature:: N¹⁰-(trifluoroacetyl)pteroic acid; With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 20h;

tert-butyl N-(6-aminohexyl)carbamate; In N,N-dimethyl-formamide; for 24h;
DOI:10.1016/j.bmcl.2004.01.105

Reference yield:

: pteroic acid

: 718605-04-0
(6-{4-[(2-Amino-4-oxo-1,4-dihydro-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-hexyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 72 h / 60 - 65 °C

1.2: 89 percent / H₂O / ethanol / 1 h / Heating

2.1: iPr₂NEt; N-hydroxysuccinimide; 1-[3-(dimethylaminopropyl)]-3-ethylcarbodiimide*HCl / dimethylformamide / 20 h

2.2: 94 percent / dimethylformamide / 24 h

With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.01.105