2-benzyloxycarbonylamino-3-{4-[6-(tert-butyl-dimethyl-silanyloxymethyl)-5-oxo-5,6-dihydro-2H-pyran-2-yloxy]-phenyl}-propionic acid methyl ester

Base Information

Chemical Name:2-benzyloxycarbonylamino-3-{4-[6-(tert-butyl-dimethyl-silanyloxymethyl)-5-oxo-5,6-dihydro-2H-pyran-2-yloxy]-phenyl}-propionic acid methyl ester
CAS No.:623157-79-9
Molecular Formula:C₃₀H₃₉NO₈Si
Molecular Weight:569.727
Hs Code.:

2-benzyloxycarbonylamino-3-{4-[6-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-5-oxo-5,6-dihydro-2<i>H</i>-pyran-2-yloxy]-phenyl}-propionic acid methyl ester

Synonyms:2-benzyloxycarbonylamino-3-{4-[6-(tert-butyl-dimethyl-silanyloxymethyl)-5-oxo-5,6-dihydro-2H-pyran-2-yloxy]-phenyl}-propionic acid methyl ester

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Chemical Property of 2-benzyloxycarbonylamino-3-{4-[6-(tert-butyl-dimethyl-silanyloxymethyl)-5-oxo-5,6-dihydro-2H-pyran-2-yloxy]-phenyl}-propionic acid methyl ester

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Technology Process of 2-benzyloxycarbonylamino-3-{4-[6-(tert-butyl-dimethyl-silanyloxymethyl)-5-oxo-5,6-dihydro-2H-pyran-2-yloxy]-phenyl}-propionic acid methyl ester

There total 1 articles about 2-benzyloxycarbonylamino-3-{4-[6-(tert-butyl-dimethyl-silanyloxymethyl)-5-oxo-5,6-dihydro-2H-pyran-2-yloxy]-phenyl}-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 13512-31-7
N-(benzyloxycarbonyl)-L-tyrosine methyl ester

: 623157-43-7
(2S,6S)-carbonic acid tert-butyl ester 6-(tert-butyl-dimethyl-silanyloxymethyl)-4-oxo-2,3-dihydro-6H-pyran-2-yl ester

: 623157-79-9
2-benzyloxycarbonylamino-3-{4-[6-(tert-butyl-dimethyl-silanyloxymethyl)-5-oxo-5,6-dihydro-2H-pyran-2-yloxy]-phenyl}-propionic acid methyl ester

Guidance literature:: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triphenylphosphine; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1021/ol060254a

Reference yield: 89.0%

: 623157-79-9
2-benzyloxycarbonylamino-3-{4-[6-(tert-butyl-dimethyl-silanyloxymethyl)-5-oxo-5,6-dihydro-2H-pyran-2-yloxy]-phenyl}-propionic acid methyl ester

: (S)-2-Benzyloxycarbonylamino-3-{4-[(2S,5R,6S)-6-(tert-butyl-dimethyl-silanyloxymethyl)-5-hydroxy-5,6-dihydro-2H-pyran-2-yloxy]-phenyl}-propionic acid methyl ester

Guidance literature:: With sodium tetrahydroborate; In methanol; dichloromethane; at -24 ℃; for 1h;
DOI:10.1021/ol060254a

Reference yield:

: 623157-79-9
2-benzyloxycarbonylamino-3-{4-[6-(tert-butyl-dimethyl-silanyloxymethyl)-5-oxo-5,6-dihydro-2H-pyran-2-yloxy]-phenyl}-propionic acid methyl ester

: C₅₃H₈₃NO₁₆Si₂

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / NaBH₄ / methanol; CH₂Cl₂ / 1 h / -24 °C

2: 85 percent / Pd₂(dba)3*CHCl₃; PPh₃ / CH₂Cl₂ / 2 h / 0 °C

3: 90 percent / NaBH₄ / methanol; CH₂Cl₂ / 1 h / -24 °C

4: 95 percent / DCC; DMAP / CH₂Cl₂ / 6 h / 0 °C

5: 86 percent / N-methylmorpholine N-oxide / OsO₄ / CH₂Cl₂; H₂O / 12 h

6: 81 percent / CSA / CH₂Cl₂ / 6 h

With dmap; sodium tetrahydroborate; camphor-10-sulfonic acid; 4-methylmorpholine N-oxide; dicyclohexyl-carbodiimide; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; osmium(VIII) oxide; triphenylphosphine; In methanol; dichloromethane; water;
DOI:10.1021/ol060254a