(2S,4S,5S)-5-Amino-6-cyclohexyl-2,4-dihydroxy-2-isobutyl-hexanoic acid isobutyl-amide; hydrochloride

Base Information

Chemical Name:(2S,4S,5S)-5-Amino-6-cyclohexyl-2,4-dihydroxy-2-isobutyl-hexanoic acid isobutyl-amide; hydrochloride
CAS No.:118233-55-9
Molecular Formula:C₂₀H₄₀N₂O₃*ClH
Molecular Weight:393.01
Hs Code.:

Synonyms:(2S,4S,5S)-5-Amino-6-cyclohexyl-2,4-dihydroxy-2-isobutyl-hexanoic acid isobutyl-amide; hydrochloride

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Chemical Property of (2S,4S,5S)-5-Amino-6-cyclohexyl-2,4-dihydroxy-2-isobutyl-hexanoic acid isobutyl-amide; hydrochloride

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Technology Process of (2S,4S,5S)-5-Amino-6-cyclohexyl-2,4-dihydroxy-2-isobutyl-hexanoic acid isobutyl-amide; hydrochloride

There total 5 articles about (2S,4S,5S)-5-Amino-6-cyclohexyl-2,4-dihydroxy-2-isobutyl-hexanoic acid isobutyl-amide; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110613-85-9
(2S,3S,5S)-N-isobutyl-2-<<(tert-butyloxy)carbonyl>amino>-1-cyclohexyl-3,5-dihydroxy-7-methyloctane-5-carboxamide

: 118233-55-9
(2S,4S,5S)-5-Amino-6-cyclohexyl-2,4-dihydroxy-2-isobutyl-hexanoic acid isobutyl-amide; hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 1h; Ambient temperature;
DOI:10.1021/jm00394a008

Reference yield:

: 98105-42-1
(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal

: 118233-55-9
(2S,4S,5S)-5-Amino-6-cyclohexyl-2,4-dihydroxy-2-isobutyl-hexanoic acid isobutyl-amide; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-butyllithium, 2.) ClTi(O-iPr)3

2: 3-chloroperoxybenzoic acid / CH₂Cl₂ / 18 h / Ambient temperature

3: 25 percent / tetrahydrofuran; diethyl ether / 0.75 h / 0 °C

4: HCl(g) / dioxane / 1 h / Ambient temperature

With triisopropoxytitanium(IV) chloride; hydrogenchloride; n-butyllithium; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane;
DOI:10.1021/jm00394a008

Reference yield:

: 77077-15-7
N-isobutylmethacrylamide

: 118233-55-9
(2S,4S,5S)-5-Amino-6-cyclohexyl-2,4-dihydroxy-2-isobutyl-hexanoic acid isobutyl-amide; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-butyllithium, 2.) ClTi(O-iPr)3

2: 3-chloroperoxybenzoic acid / CH₂Cl₂ / 18 h / Ambient temperature

3: 25 percent / tetrahydrofuran; diethyl ether / 0.75 h / 0 °C

4: HCl(g) / dioxane / 1 h / Ambient temperature

With triisopropoxytitanium(IV) chloride; hydrogenchloride; n-butyllithium; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane;
DOI:10.1021/jm00394a008