{(2E)-1-[trans-4-(cyanomethyl)cyclohexyl]-1,3-dihydro-2H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-ylidene}cyanamide trifluoroacetate

Base Information

Chemical Name:{(2E)-1-[trans-4-(cyanomethyl)cyclohexyl]-1,3-dihydro-2H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-ylidene}cyanamide trifluoroacetate
CAS No.:1607792-61-9
Molecular Formula:C₂HF₃O₂*C₁₇H₁₆N₆S
Molecular Weight:450.444
Hs Code.:

Synonyms:{(2E)-1-[trans-4-(cyanomethyl)cyclohexyl]-1,3-dihydro-2H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-ylidene}cyanamide trifluoroacetate

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Chemical Property of {(2E)-1-[trans-4-(cyanomethyl)cyclohexyl]-1,3-dihydro-2H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-ylidene}cyanamide trifluoroacetate

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Technology Process of {(2E)-1-[trans-4-(cyanomethyl)cyclohexyl]-1,3-dihydro-2H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-ylidene}cyanamide trifluoroacetate

There total 11 articles about {(2E)-1-[trans-4-(cyanomethyl)cyclohexyl]-1,3-dihydro-2H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-ylidene}cyanamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.6%

: 1607589-86-5
{trans-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile

: 76-05-1
trifluoroacetic acid

: 1607792-61-9
{(2E)-1-[trans-4-(cyanomethyl)cyclohexyl]-1,3-dihydro-2H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-ylidene}cyanamide trifluoroacetate

Guidance literature:: {trans-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile; With N-cyanodiphenylcarbonimidate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 100 ℃; for 2h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 69627-02-7,107818-20-2
thieno[3,2-b]pyridin-7-ol

: 1607792-61-9
{(2E)-1-[trans-4-(cyanomethyl)cyclohexyl]-1,3-dihydro-2H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-ylidene}cyanamide trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrabutylammonium nitrate / dichloromethane / -5 °C

1.2: -5 - 20 °C

2.1: trichlorophosphate / 1 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 90 °C

4.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; N-cyanodiphenylcarbonimidate / acetonitrile / 2 h / 100 °C

With palladium 10% on activated carbon; hydrogen; tetrabutylammonium nitrate; N-cyanodiphenylcarbonimidate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; dichloromethane; isopropyl alcohol; acetonitrile;

Reference yield:

: 104515-05-1,905735-40-2
6-nitrothieno[3,2-b]pyridin-7-ol

: 1607792-61-9
{(2E)-1-[trans-4-(cyanomethyl)cyclohexyl]-1,3-dihydro-2H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-ylidene}cyanamide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 1 h / Reflux

2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 90 °C

3: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; N-cyanodiphenylcarbonimidate / acetonitrile / 2 h / 100 °C

With palladium 10% on activated carbon; hydrogen; N-cyanodiphenylcarbonimidate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; isopropyl alcohol; acetonitrile;