13β-chloro-13-deoxy-7-(triethylsilyl)baccatin III

Base Information

• Chemical Name: 13β-chloro-13-deoxy-7-(triethylsilyl)baccatin III
• CAS No.: 172481-22-0
• Molecular Formula: C₃₇H₅₁ClO₁₀Si
• Molecular Weight: 719.344
• Mol file: 172481-22-0.mol

Synonyms:13β-chloro-13-deoxy-7-(triethylsilyl)baccatin III

Chemical Property of 13β-chloro-13-deoxy-7-(triethylsilyl)baccatin III

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 13β-chloro-13-deoxy-7-(triethylsilyl)baccatin III

There total 2 articles about 13β-chloro-13-deoxy-7-(triethylsilyl)baccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

7-(triethylsilyl)baccatin III (115437-21-3) → 13β-chloro-13-deoxy-7-(triethylsilyl)baccatin III (172481-22-0)

Guidance literature:

With pyridine; thionyl chloride; In dichloromethane; for 0.25h; Ambient temperature;

DOI:10.1016/0040-4020(95)00823-Q

Reference yield:

7-(triethylsilyl)-13-(trifluoromethanesulfonyl)baccatin III (172481-24-2) → 13β-chloro-13-deoxy-7-(triethylsilyl)baccatin III (172481-22-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / NaN₃ / dimethylformamide; H₂O / 2 h / 60 °C

2: 76 percent / SOCl₂, pyridine / CH₂Cl₂ / 0.25 h / Ambient temperature

With pyridine; thionyl chloride; sodium azide; In dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/0040-4020(95)00823-Q

Reference yield: 71.0%

13β-chloro-13-deoxy-7-(triethylsilyl)baccatin III (172481-22-0) → C37H52O11Si

Guidance literature:

With sodium azide; In water; N,N-dimethyl-formamide; at 60 ℃; for 2h;

DOI:10.1016/0040-4020(95)00823-Q

upstream raw materials:

7-(triethylsilyl)baccatin III

7-(triethylsilyl)-13-(trifluoromethanesulfonyl)baccatin III

Refernces