8-Fluoro-1,2,3,4-tetrahydroquinoline

Base Information

• Chemical Name: 8-Fluoro-1,2,3,4-tetrahydroquinoline
• CAS No.: 75414-02-7
• Molecular Formula: C9H10 F N
• Molecular Weight: 151.184
• Hs Code.: 2933499090
• European Community (EC) Number: 831-669-4
• DSSTox Substance ID: DTXSID80505604
• Wikidata: Q82360835
• Mol file: 75414-02-7.mol

Synonyms:8-fluoro-1,2,3,4-tetrahydroquinoline;75414-02-7;SCHEMBL3115966;DTXSID80505604;MFCD09041601;AKOS000123600;BS-13436;CS-0244468;EN300-27853;N12833;8-FLUORO-1,2,3,4-TETRA HYDROQUINOLINE;Z247615872

Chemical Property of 8-Fluoro-1,2,3,4-tetrahydroquinoline

Chemical Property:

• PSA: 12.03000
• LogP: 2.32180
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 151.079727485
• Heavy Atom Count: 11
• Complexity: 138

Purity/Quality:

98.5% ^*data from raw suppliers

8-fluoro-1,2,3,4-tetrahydroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2=C(C(=CC=C2)F)NC1

Technology Process of 8-Fluoro-1,2,3,4-tetrahydroquinoline

There total 4 articles about 8-Fluoro-1,2,3,4-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

8-fluoroquinoline (394-68-3) → 8-fluoro-1,2,3,4-tetrahydroquinoline (75414-02-7)

Guidance literature:

With C₄₆H₄₉CoN₃P₄⁽²⁺⁾*2BF₄^(1-); hydrogen; potassium hydroxide; In isopropyl alcohol; acetonitrile; at 100 ℃; for 48h; under 22801.5 Torr; chemoselective reaction; Autoclave; Glovebox;

DOI:10.1021/jacs.9b11070

Reference yield: 92.0%

→ 8-fluoro-1,2,3,4-tetrahydroquinoline (75414-02-7)

Guidance literature:

With palladium diacetate; caesium carbonate; bis(pinacol)diborane; In water; at 20 ℃; for 10h; Inert atmosphere; Green chemistry;

Reference yield: 10.0%

8-fluoroquinoline (394-68-3) → quinoline (91-22-5) + 5,6,7,8-tetrahydroquinoline (10500-57-9) + 1,2,3,4-tetrahydroisoquinoline (635-46-1) + 8-fluoro-1,2,3,4-tetrahydroquinoline (75414-02-7)

Guidance literature:

With hydrogen; platinum(IV) oxide; In trifluoroacetic acid;

upstream raw materials:

8-fluoroquinoline

8-fluoro-2,3-dihydro-1H-quinolin-4-one

Downstream raw materials:

8-fluoroquinoline

Refernces

• 1、 Zhou, Chao-Zheng,Zhao, Yu-Rou,Tan, Fang-Fang,Guo, Yan-Jun,Li, Yang. "Utilization of renewable formic acid from lignocellulosic biomass for the selective hydrogenation and/or N-methylation". . p. 4724 - 4728. Retrieved 2021/09/06.
• 2、 Liu, Shuyang,Tian, Miao,Bu, Xiubin,Tian, Hua,Yang, Xiaobo. "Covalent Organic Frameworks toward Diverse Photocatalytic Aerobic Oxidations". supporting information. p. 7738 - 7744. Retrieved 2021/05/07.