(S)-7-[3-((R)-6,6-difluoro-5,7,7-trimethyl-3-thioxo-[1,4]oxazepan-5-yl)-4-fluoro-phenylamino]-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile

Base Information

Chemical Name:(S)-7-[3-((R)-6,6-difluoro-5,7,7-trimethyl-3-thioxo-[1,4]oxazepan-5-yl)-4-fluoro-phenylamino]-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile
CAS No.:1400683-07-9
Molecular Formula:C₂₃H₂₃F₃N₄OS
Molecular Weight:460.523
Hs Code.:

Synonyms:(S)-7-[3-((R)-6,6-difluoro-5,7,7-trimethyl-3-thioxo-[1,4]oxazepan-5-yl)-4-fluoro-phenylamino]-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile

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Chemical Property of (S)-7-[3-((R)-6,6-difluoro-5,7,7-trimethyl-3-thioxo-[1,4]oxazepan-5-yl)-4-fluoro-phenylamino]-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile

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Technology Process of (S)-7-[3-((R)-6,6-difluoro-5,7,7-trimethyl-3-thioxo-[1,4]oxazepan-5-yl)-4-fluoro-phenylamino]-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile

There total 10 articles about (S)-7-[3-((R)-6,6-difluoro-5,7,7-trimethyl-3-thioxo-[1,4]oxazepan-5-yl)-4-fluoro-phenylamino]-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.7%

: 7-(3-((R)-6,6-difluoro-5,7,7-trimethyl-3-thioxo-1,4-oxazepan-5-yl)-4-fluorophenylamino)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile

: 1400683-08-0
(R)-7-(3-((R)-6,6-difluoro-5,7,7-trimethyl-3-thioxo-1,4-oxazepan-5-yl)-4-fluorophenylamino)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile

: 1400683-07-9
(S)-7-[3-((R)-6,6-difluoro-5,7,7-trimethyl-3-thioxo-[1,4]oxazepan-5-yl)-4-fluoro-phenylamino]-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile

Guidance literature:: With Chiralpak AD column; In ethanol; n-heptane; Resolution of racemate;

Reference yield: 42.7%

: (R)-5-[5-(3-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine-7-ylamino)-2-fluoro-phenyl]-6,6-difluoro-5-methyl-[1,4]oxazepane-3-thione

: 1400683-08-0
(R)-7-(3-((R)-6,6-difluoro-5,7,7-trimethyl-3-thioxo-1,4-oxazepan-5-yl)-4-fluorophenylamino)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile

: 1400683-07-9
(S)-7-[3-((R)-6,6-difluoro-5,7,7-trimethyl-3-thioxo-[1,4]oxazepan-5-yl)-4-fluoro-phenylamino]-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile

Guidance literature:: With Chiralpak AD column; In ethanol; n-heptane; Purification / work up; Resolution of diastereomers;

Reference yield:

: 1357097-03-0
3-chloro-6,7-dihydro-5H-cyclopentapyridine 1-oxide

: 1400683-08-0
(R)-7-(3-((R)-6,6-difluoro-5,7,7-trimethyl-3-thioxo-1,4-oxazepan-5-yl)-4-fluorophenylamino)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile

: 1400683-07-9
(S)-7-[3-((R)-6,6-difluoro-5,7,7-trimethyl-3-thioxo-[1,4]oxazepan-5-yl)-4-fluoro-phenylamino]-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: 20 h / 110 °C

2: sodium hydroxide; water / methanol / 1.5 h / 20 °C

3: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 1 h / 20 °C

4: nido-decaborane; methanol / dichloromethane / 22 h / 23 °C

5: Lawessons reagent / 1,4-dioxane / 3 h / 23 - 80 °C

6: Chiralpak AD column / n-heptane; ethanol / Resolution of diastereomers

With Lawessons reagent; methanol; nido-decaborane; water; sulfur trioxide pyridine complex; triethylamine; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; n-heptane; dichloromethane; dimethyl sulfoxide;