N-(benzyloxycarbonyl)-N-(tert-butoxycarbonyl)propargylamine

Base Information

• Chemical Name: N-(benzyloxycarbonyl)-N-(tert-butoxycarbonyl)propargylamine
• CAS No.: 848303-77-5
• Molecular Formula: C₁₆H₁₉NO₄
• Molecular Weight: 289.331
• Mol file: 848303-77-5.mol

Synonyms:N-(benzyloxycarbonyl)-N-(tert-butoxycarbonyl)propargylamine

Chemical Property of N-(benzyloxycarbonyl)-N-(tert-butoxycarbonyl)propargylamine

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N-(benzyloxycarbonyl)-N-(tert-butoxycarbonyl)propargylamine

There total 1 articles about N-(benzyloxycarbonyl)-N-(tert-butoxycarbonyl)propargylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

di-tert-butyl dicarbonate (24424-99-5) + prop-2-ynyl-carbamic acid benzyl ester (120539-91-5) → N-(benzyloxycarbonyl)-N-(tert-butoxycarbonyl)propargylamine (848303-77-5)

Guidance literature:

With dmap; In acetonitrile; at 20 ℃; for 4h;

DOI:10.1016/j.tet.2006.06.104

Reference yield: 40.0%

N-(benzyloxycarbonyl)-N-(tert-butoxycarbonyl)propargylamine (848303-77-5) + methyl (3aRS,4SR,9bSR)-1,5-dibenzyl-4-methoxy-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinoline-8-carboxylate → methyl (3aRS,4RS,9bSR)-4-[3-(benzyloxycarbonyl-tert-butoxycarbonylamino)-prop-1-ynyl]-1,5-dibenzyl-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinoline-8-carboxylate

Guidance literature:

With copper(I) bromide; In water; for 3h; sonication;

DOI:10.1016/j.tetlet.2005.01.004

Reference yield: 32.0%

(3aRS,4RS,9bSR)-8-bromo-1,5-dibenzyl-2,3,3a,4,5,9b-hexahydro-4-hydroxy-1H-pyrrolo[3,2-c]quinoline + N-(benzyloxycarbonyl)-N-(tert-butoxycarbonyl)propargylamine (848303-77-5) → C41H42BrN3O4 + (3aRS,4RS,9bSR)-4-[3-(benzyloxycarbonyl-tert-butyloxycarbonylamino)prop-1-ynyl]-8-bromo-1,5-dibenzyl-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinoline

Guidance literature:

With copper(I) bromide; In water; at 40 - 45 ℃; for 3h; sonication;

DOI:10.1016/j.tet.2006.06.104

upstream raw materials:

di-tert-butyl dicarbonate

prop-2-ynyl-carbamic acid benzyl ester