2-(4-fluoro-2-nitrophenylthio)-5-hydroxy-N,N-dimethylbenzamide

Base Information

Chemical Name:2-(4-fluoro-2-nitrophenylthio)-5-hydroxy-N,N-dimethylbenzamide
CAS No.:1004534-42-2
Molecular Formula:C₁₅H₁₃FN₂O₄S
Molecular Weight:336.344
Hs Code.:

Synonyms:2-(4-fluoro-2-nitrophenylthio)-5-hydroxy-N,N-dimethylbenzamide

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Chemical Property of 2-(4-fluoro-2-nitrophenylthio)-5-hydroxy-N,N-dimethylbenzamide

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Technology Process of 2-(4-fluoro-2-nitrophenylthio)-5-hydroxy-N,N-dimethylbenzamide

There total 4 articles about 2-(4-fluoro-2-nitrophenylthio)-5-hydroxy-N,N-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1004534-35-3
2-(4-fluoro-2-nitrophenylthio)-5-methoxy-N,N-dimethylbenzamide

: 1004534-42-2
2-(4-fluoro-2-nitrophenylthio)-5-hydroxy-N,N-dimethylbenzamide

Guidance literature:: With boron tribromide; In dichloromethane; at 100 ℃; for 0.333333h; Irradiation;
DOI:10.1021/jm070685e

Reference yield:

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 1004534-42-2
2-(4-fluoro-2-nitrophenylthio)-5-hydroxy-N,N-dimethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; sodium nitrite; hydrogenchloride / water / 1 h / -10 °C / Inert atmosphere

1.2: 0.5 h / 80 °C / Inert atmosphere

1.3: 16 h / Reflux; Inert atmosphere

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

3.1: boron tribromide dimethyl sulfide complex / dichloromethane; 1,2-dichloro-ethane / 15 h / 70 °C / Inert atmosphere

With hydrogenchloride; oxalyl dichloride; boron tribromide dimethyl sulfide complex; sodium hydroxide; sodium nitrite; In dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bioorg.2020.103654

Reference yield:

: 446-09-3
2-bromo-5-fluoronitrobenzene

: 1004534-42-2
2-(4-fluoro-2-nitrophenylthio)-5-hydroxy-N,N-dimethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; sodium nitrite; hydrogenchloride / water / 1 h / -10 °C / Inert atmosphere

1.2: 0.5 h / 80 °C / Inert atmosphere

1.3: 16 h / Reflux; Inert atmosphere

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

3.1: boron tribromide dimethyl sulfide complex / dichloromethane; 1,2-dichloro-ethane / 15 h / 70 °C / Inert atmosphere

With hydrogenchloride; oxalyl dichloride; boron tribromide dimethyl sulfide complex; sodium hydroxide; sodium nitrite; In dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bioorg.2020.103654