N-phthaloyl glutamic acid α-methyl ester

Base Information

• Chemical Name: N-phthaloyl glutamic acid α-methyl ester
• CAS No.: 150823-38-4
• Molecular Formula: C₁₄H₁₃NO₆
• Molecular Weight: 291.26
• Mol file: 150823-38-4.mol

Synonyms:N-phthaloyl glutamic acid α-methyl ester

Chemical Property of N-phthaloyl glutamic acid α-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-phthaloyl glutamic acid α-methyl ester

There total 2 articles about N-phthaloyl glutamic acid α-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phthalic anhydride (85-44-9) → N,N-phthaloyl-D-glutamic acid-1-methyl ester (42294-25-7,101610-17-7,150823-38-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 140 - 150 °C / anschliessendes Erhitzen mit Acetanhydrid auf 100-110grad

2: methanol

With methanol;

DOI:10.1021/ja01548a036

Reference yield:

phthalic anhydride (85-44-9) → N-phthaloyl glutamic acid α-methyl ester (150823-38-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 140 - 150 °C / Erhitzen des Reaktionsprodukts mit Acetanhydrid auf 100grad

2: methanol

With methanol;

DOI:10.1021/ja01548a036

Reference yield:

N-phthaloyl glutamic acid α-methyl ester (150823-38-4) → 3-oxo-2-phenylhydrazono-6-phthalimido-heptanedioic acid-1-ethyl ester-7-methyl ester (102951-39-3)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether; phosphorus (V)-chloride / Behandeln des Reaktionsprodukts in Aether mit der Magnesium-Verbindung des Malonsaeure-diaethylesters

2: toluene-4-sulfonic acid-monohydrate

3: aqueous ethanol; sodium acetate

With diethyl ether; ethanol; phosphorus pentachloride; sodium acetate; toluene-4-sulfonic acid;

DOI:10.1021/ja01601a048

upstream raw materials:

phthalic anhydride

Downstream raw materials:

(R)-2-amino-6-diazo-5-oxo-hexanoic acid

6-diazo-5-oxonorleucine

N²,N²-phthaloyl-glutamine-methyl ester

3-oxo-2-phenylhydrazono-6-phthalimido-heptanedioic acid-1-ethyl ester-7-methyl ester