diethyl (3S)-3-[((3-(N-benzyloxycarbonyl)amino-3-methoxycarbonyl)propyl(hydroxy)phosphinyl)]pentan-1,5-dioate

Base Information

• Chemical Name: diethyl (3S)-3-[((3-(N-benzyloxycarbonyl)amino-3-methoxycarbonyl)propyl(hydroxy)phosphinyl)]pentan-1,5-dioate
• CAS No.: 936234-08-1
• Molecular Formula: C₂₂H₃₂NO₁₀P
• Molecular Weight: 501.471
• Mol file: 936234-08-1.mol

Synonyms:diethyl (3S)-3-[((3-(N-benzyloxycarbonyl)amino-3-methoxycarbonyl)propyl(hydroxy)phosphinyl)]pentan-1,5-dioate

Chemical Property of diethyl (3S)-3-[((3-(N-benzyloxycarbonyl)amino-3-methoxycarbonyl)propyl(hydroxy)phosphinyl)]pentan-1,5-dioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl (3S)-3-[((3-(N-benzyloxycarbonyl)amino-3-methoxycarbonyl)propyl(hydroxy)phosphinyl)]pentan-1,5-dioate

There total 2 articles about diethyl (3S)-3-[((3-(N-benzyloxycarbonyl)amino-3-methoxycarbonyl)propyl(hydroxy)phosphinyl)]pentan-1,5-dioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

(S)-2-benzyloxycarbonylamino-4-hydroxyphosphinoyl-butyric acid methyl ester (864682-69-9) + diethyl glutaconate (2049-67-4) → diethyl (3S)-3-[((3-(N-benzyloxycarbonyl)amino-3-methoxycarbonyl)propyl(hydroxy)phosphinyl)]pentan-1,5-dioate (936234-08-1)

Guidance literature:

With N,O-bis-(trimethylsilyl)-acetamide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm901523t

Reference yield:

(S)-2-benzyloxycarbonylamino-4-hydroxyphosphinoyl-butyric acid methyl ester (864682-69-9) + diethyl glutaconate (857819-57-9) → C9H17O6P + diethyl (3S)-3-[((3-(N-benzyloxycarbonyl)amino-3-methoxycarbonyl)propyl(hydroxy)phosphinyl)]pentan-1,5-dioate (936234-08-1)

Guidance literature:

(S)-2-benzyloxycarbonylamino-4-hydroxyphosphinoyl-butyric acid methyl ester; diethyl glutaconate; With N,O-bis(triethylsilyl)acetamide; In dichloromethane; at 0 - 20 ℃;

With hydrogenchloride; In dichloromethane; water;

With hydrogenchloride; more than 3 stages;

upstream raw materials:

(S)-2-benzyloxycarbonylamino-4-hydroxyphosphinoyl-butyric acid methyl ester

diethyl glutaconate

diethyl glutaconate