2-((tert-butyldimethylsilyloxy)(5-phenylindan-2-yl)methyl)-5-(pyridin-2-yl)oxazole

Base Information

Chemical Name:2-((tert-butyldimethylsilyloxy)(5-phenylindan-2-yl)methyl)-5-(pyridin-2-yl)oxazole
CAS No.:1289563-82-1
Molecular Formula:C₃₀H₃₄N₂O₂Si
Molecular Weight:482.698
Hs Code.:

Synonyms:2-((tert-butyldimethylsilyloxy)(5-phenylindan-2-yl)methyl)-5-(pyridin-2-yl)oxazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-((tert-butyldimethylsilyloxy)(5-phenylindan-2-yl)methyl)-5-(pyridin-2-yl)oxazole

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Technology Process of 2-((tert-butyldimethylsilyloxy)(5-phenylindan-2-yl)methyl)-5-(pyridin-2-yl)oxazole

There total 13 articles about 2-((tert-butyldimethylsilyloxy)(5-phenylindan-2-yl)methyl)-5-(pyridin-2-yl)oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 109-04-6
2-bromo-pyridine

: 1289563-80-9
2-((tert-butyldimethylsilyloxy)(5-phenylindan-2-yl)methyl)-5-(tributylstannyl)oxazole

: 1289563-82-1
2-((tert-butyldimethylsilyloxy)(5-phenylindan-2-yl)methyl)-5-(pyridin-2-yl)oxazole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; for 16h; Reflux; Inert atmosphere;
DOI:10.1021/jm101597x

Reference yield: 22.0%

: 1289563-82-1
2-((tert-butyldimethylsilyloxy)(5-phenylindan-2-yl)methyl)-5-(pyridin-2-yl)oxazole

Guidance literature:

Reference yield:

: 13623-25-1
6-methoxy-2,3-dihydro-1H-inden-1-one

: 1289563-82-1
2-((tert-butyldimethylsilyloxy)(5-phenylindan-2-yl)methyl)-5-(pyridin-2-yl)oxazole

Guidance literature:: Multi-step reaction with 12 steps

1.1: sodium hydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

2.1: palladium 10% on activated carbon; perchloric acid; hydrogen; acetic acid / 16 h

3.1: water; hydrogen bromide; acetic acid / 2 h / Inert atmosphere; Reflux

4.1: sulfuric acid / 1 h / Inert atmosphere; Reflux

5.1: pyridine / 0 - 20 °C / Inert atmosphere

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 16 h / Reflux; Inert atmosphere

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

8.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

9.1: borane-THF / tetrahydrofuran / 1 h / 20 °C

9.2: 0.67 h / -78 °C

9.3: 2 h / -78 °C

10.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

11.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C

12.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 16 h / Reflux; Inert atmosphere

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; perchloric acid; borane-THF; sulfuric acid; palladium 10% on activated carbon; water; hydrogen bromide; hydrogen; sodium hydride; sodium carbonate; Dess-Martin periodane; acetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 6.1: Suzuki coupling / 12.1: Stille coupling;
DOI:10.1021/jm101597x