((2R,3S,4R)-3-(benzyloxy)-4-(benzyloxymethyl)-1-nonylazetidin-2-yl)methanol

Base Information

Chemical Name:((2R,3S,4R)-3-(benzyloxy)-4-(benzyloxymethyl)-1-nonylazetidin-2-yl)methanol
CAS No.:1366423-16-6
Molecular Formula:C₂₈H₄₁NO₃
Molecular Weight:439.638
Hs Code.:

Synonyms:((2R,3S,4R)-3-(benzyloxy)-4-(benzyloxymethyl)-1-nonylazetidin-2-yl)methanol

Suppliers and Price of ((2R,3S,4R)-3-(benzyloxy)-4-(benzyloxymethyl)-1-nonylazetidin-2-yl)methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ((2R,3S,4R)-3-(benzyloxy)-4-(benzyloxymethyl)-1-nonylazetidin-2-yl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ((2R,3S,4R)-3-(benzyloxy)-4-(benzyloxymethyl)-1-nonylazetidin-2-yl)methanol

There total 13 articles about ((2R,3S,4R)-3-(benzyloxy)-4-(benzyloxymethyl)-1-nonylazetidin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 112-31-2
caprinaldehyde

: 1366422-72-1
(2R,3R,4R)-3-(benzyloxy)-2-(benzyloxymethyl)-4-((tertbutyldimethylsilyloxy)methyl)azetidine

: 1366423-16-6
((2R,3S,4R)-3-(benzyloxy)-4-(benzyloxymethyl)-1-nonylazetidin-2-yl)methanol

Guidance literature:: caprinaldehyde; (2R,3R,4R)-3-(benzyloxy)-2-(benzyloxymethyl)-4-((tertbutyldimethylsilyloxy)methyl)azetidine; With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 16h; Inert atmosphere;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jo202054g

Reference yield:

: 1366423-06-4
C₈H₁₄O₄

: 1366423-16-6
((2R,3S,4R)-3-(benzyloxy)-4-(benzyloxymethyl)-1-nonylazetidin-2-yl)methanol

Guidance literature:: Multi-step reaction with 10 steps

1.1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

2.1: sodium azide; water; ammonium chloride / ethyl methyl ether / 5 h / Reflux

3.1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran; mineral oil / 20 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran / -78 - 0 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

6.1: hydrogenchloride; water / methanol / 40 °C

7.1: dmap; triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

8.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere

9.1: naphthalene; sodium / 1,2-dimethoxyethane / -60 °C / Inert atmosphere

10.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 16 h / 20 °C / Inert atmosphere

10.2: 4 h / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; lithium aluminium tetrahydride; sodium azide; naphthalene; di-isopropyl azodicarboxylate; water; sodium; tetra-(n-butyl)ammonium iodide; sodium tris(acetoxy)borohydride; sodium hydride; ammonium chloride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethyl methyl ether; dichloromethane; 1,2-dichloro-ethane; mineral oil; 8.1: Mitsunobu reaction;
DOI:10.1021/jo202054g

Reference yield:

: 1366423-08-6
C₁₅H₂₁N₃O₄

: 1366423-16-6
((2R,3S,4R)-3-(benzyloxy)-4-(benzyloxymethyl)-1-nonylazetidin-2-yl)methanol

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran; mineral oil / 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / -78 - 0 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

4.1: hydrogenchloride; water / methanol / 40 °C

5.1: dmap; triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

6.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere

7.1: naphthalene; sodium / 1,2-dimethoxyethane / -60 °C / Inert atmosphere

8.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 16 h / 20 °C / Inert atmosphere

8.2: 4 h / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; lithium aluminium tetrahydride; naphthalene; di-isopropyl azodicarboxylate; water; sodium; tetra-(n-butyl)ammonium iodide; sodium tris(acetoxy)borohydride; sodium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; 1,2-dichloro-ethane; mineral oil; 6.1: Mitsunobu reaction;
DOI:10.1021/jo202054g