(1R,5'R)-1-p-nitrobenzoic acid-1-(2',2'-dimethyl-[1',3']dioxolan-4'-yl)-3-phenyl-prop-2-ynyl

Base Information

Chemical Name:(1R,5'R)-1-p-nitrobenzoic acid-1-(2',2'-dimethyl-[1',3']dioxolan-4'-yl)-3-phenyl-prop-2-ynyl
CAS No.:267665-92-9
Molecular Formula:C₂₁H₁₉NO₆
Molecular Weight:381.385
Hs Code.:

Synonyms:(1R,5'R)-1-p-nitrobenzoic acid-1-(2',2'-dimethyl-[1',3']dioxolan-4'-yl)-3-phenyl-prop-2-ynyl

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Chemical Property of (1R,5'R)-1-p-nitrobenzoic acid-1-(2',2'-dimethyl-[1',3']dioxolan-4'-yl)-3-phenyl-prop-2-ynyl

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Technology Process of (1R,5'R)-1-p-nitrobenzoic acid-1-(2',2'-dimethyl-[1',3']dioxolan-4'-yl)-3-phenyl-prop-2-ynyl

There total 3 articles about (1R,5'R)-1-p-nitrobenzoic acid-1-(2',2'-dimethyl-[1',3']dioxolan-4'-yl)-3-phenyl-prop-2-ynyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 208114-17-4
(1S,5'R)-1-(2',2'-dimethyl-[1',3']dioxolan-4-yl)-3-phenyl-prop-2-yn-ol

: 62-23-7
4-nitro-benzoic acid

: 267665-92-9
(1R,5'R)-1-p-nitrobenzoic acid-1-(2',2'-dimethyl-[1',3']dioxolan-4'-yl)-3-phenyl-prop-2-ynyl

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; benzene; at 20 ℃;
DOI:10.1002/jccs.200000004

Reference yield:

: 4688-38-4
(2R,3S)-1,2-O-isopropylidene-4-pentyne-1,2,3-triol

: 267665-92-9
(1R,5'R)-1-p-nitrobenzoic acid-1-(2',2'-dimethyl-[1',3']dioxolan-4'-yl)-3-phenyl-prop-2-ynyl

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / PdIPh₃P)4; CuI; pyrrolidine / 2.5 h

2: 70 percent / PPh₃; DEAD / tetrahydrofuran; benzene / 20 °C

With pyrrolidine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; benzene; 1: Phenylation / 2: Esterification;
DOI:10.1002/jccs.200000004

Reference yield:

: 591-50-4
iodobenzene

: 267665-92-9
(1R,5'R)-1-p-nitrobenzoic acid-1-(2',2'-dimethyl-[1',3']dioxolan-4'-yl)-3-phenyl-prop-2-ynyl

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / PdIPh₃P)4; CuI; pyrrolidine / 2.5 h

2: 70 percent / PPh₃; DEAD / tetrahydrofuran; benzene / 20 °C

With pyrrolidine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; benzene; 1: Phenylation / 2: Esterification;
DOI:10.1002/jccs.200000004