diethyl 2-(acetylamino)-2-<<3-(chloromethyl)phenyl>methyl>propanedioic acid

Base Information

Chemical Name:diethyl 2-(acetylamino)-2-<<3-(chloromethyl)phenyl>methyl>propanedioic acid
CAS No.:120667-60-9
Molecular Formula:C₁₇H₂₂ClNO₅
Molecular Weight:355.818
Hs Code.:

Synonyms:diethyl 2-(acetylamino)-2-<<3-(chloromethyl)phenyl>methyl>propanedioic acid

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Chemical Property of diethyl 2-(acetylamino)-2-<<3-(chloromethyl)phenyl>methyl>propanedioic acid

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Technology Process of diethyl 2-(acetylamino)-2-<<3-(chloromethyl)phenyl>methyl>propanedioic acid

There total 6 articles about diethyl 2-(acetylamino)-2-<<3-(chloromethyl)phenyl>methyl>propanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 63999-86-0
diethyl <3-(hydroxymethyl)benzyl>acetamidomalonate

: 120667-60-9
diethyl 2-(acetylamino)-2-<<3-(chloromethyl)phenyl>methyl>propanedioic acid

Guidance literature:: With thionyl chloride; In dichloromethane; for 20h; Heating;
DOI:10.1021/jm00092a005

Reference yield:

: 2719-40-6
1-methyl-2-chloro-4-chloromethylbenzene

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 120667-60-9
diethyl 2-(acetylamino)-2-<<3-(chloromethyl)phenyl>methyl>propanedioic acid

Guidance literature:: With sodium; In tetrahydrofuran; ethanol; n-heptane;

Reference yield:

: 52117-00-7
2-Acetylamino-2-[(3-cyanophenyl)-methyl]-malonic acid diethyl ester

: 120667-60-9
diethyl 2-(acetylamino)-2-<<3-(chloromethyl)phenyl>methyl>propanedioic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / H₂, conc. aq. HCl / 10percent Pd/C / ethanol; CHCl₃ / 24 h / Ambient temperature

2: 97 percent / aq. NaOH, NaNO₂ / 5 h / Heating

3: 97 percent / thionyl chloride / CH₂Cl₂ / 20 h / Heating

With hydrogenchloride; sodium hydroxide; thionyl chloride; hydrogen; sodium nitrite; palladium on activated charcoal; In ethanol; dichloromethane; chloroform;
DOI:10.1021/jm00092a005