3-methoxy-4-(4-isopropylamino-5-nitropyrimidin-2-ylamino)-N-(4-methylpiperazin-1-yl)benzamide

Base Information

Chemical Name:3-methoxy-4-(4-isopropylamino-5-nitropyrimidin-2-ylamino)-N-(4-methylpiperazin-1-yl)benzamide
CAS No.:1350545-35-5
Molecular Formula:C₂₀H₂₈N₈O₄
Molecular Weight:444.494
Hs Code.:

Synonyms:3-methoxy-4-(4-isopropylamino-5-nitropyrimidin-2-ylamino)-N-(4-methylpiperazin-1-yl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-methoxy-4-(4-isopropylamino-5-nitropyrimidin-2-ylamino)-N-(4-methylpiperazin-1-yl)benzamide

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Technology Process of 3-methoxy-4-(4-isopropylamino-5-nitropyrimidin-2-ylamino)-N-(4-methylpiperazin-1-yl)benzamide

There total 1 articles about 3-methoxy-4-(4-isopropylamino-5-nitropyrimidin-2-ylamino)-N-(4-methylpiperazin-1-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.1%

: 890094-38-9
2-chloro-N-isopropyl-5-nitropyrimidin-4-amine

: 1350545-83-3
4-amino-3-methoxy-N-(4-methylpiperazin-1-yl)benzamide

: 1350545-35-5
3-methoxy-4-(4-isopropylamino-5-nitropyrimidin-2-ylamino)-N-(4-methylpiperazin-1-yl)benzamide

Guidance literature:: In butan-1-ol; at 90 ℃; for 4.5h;

Reference yield: 75.0%

: 1350545-35-5
3-methoxy-4-(4-isopropylamino-5-nitropyrimidin-2-ylamino)-N-(4-methylpiperazin-1-yl)benzamide

: 1350545-58-2
3-methoxy-4-(4-isopropylamino-5-aminopyrimidin-2-ylamino)-N-(4-methylpiperazin-1-yl)benzamide

Guidance literature:: With iron; ammonium chloride; In ethanol; water; at 90 ℃; for 3.5h;

Reference yield:

: 1350545-35-5
3-methoxy-4-(4-isopropylamino-5-nitropyrimidin-2-ylamino)-N-(4-methylpiperazin-1-yl)benzamide

: 1350544-68-1
3-methoxy-4-(9-isopropyl-8-phenylamino-9H-purin-2-ylamino)-N-(4-methylpiperazin-1-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium chloride; iron / water; ethanol / 3.5 h / 90 °C

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 10.5 h / 20 °C / Reflux

With iron; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; water;