methyl 3-{[(2R,6R)-1-benzyl-2,6-dimethylpiperidin-4-yl]amino}-5-fluoro-2-methylbenzoate

Base Information

Chemical Name:methyl 3-{[(2R,6R)-1-benzyl-2,6-dimethylpiperidin-4-yl]amino}-5-fluoro-2-methylbenzoate
CAS No.:1403595-35-6
Molecular Formula:C₂₃H₂₉FN₂O₂
Molecular Weight:384.494
Hs Code.:

Synonyms:methyl 3-{[(2R,6R)-1-benzyl-2,6-dimethylpiperidin-4-yl]amino}-5-fluoro-2-methylbenzoate

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Chemical Property of methyl 3-{[(2R,6R)-1-benzyl-2,6-dimethylpiperidin-4-yl]amino}-5-fluoro-2-methylbenzoate

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Technology Process of methyl 3-{[(2R,6R)-1-benzyl-2,6-dimethylpiperidin-4-yl]amino}-5-fluoro-2-methylbenzoate

There total 1 articles about methyl 3-{[(2R,6R)-1-benzyl-2,6-dimethylpiperidin-4-yl]amino}-5-fluoro-2-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 697739-04-1
3-amino-5-fluoro-2-methylbenzoic acid methyl ester

: (2R,6R)-1-benzyl-2,6-dimethylpiperidin-4-one

: 1403595-35-6
methyl 3-{[(2R,6R)-1-benzyl-2,6-dimethylpiperidin-4-yl]amino}-5-fluoro-2-methylbenzoate

Guidance literature:: 3-amino-5-fluoro-2-methylbenzoic acid methyl ester; (2R,6R)-1-benzyl-2,6-dimethylpiperidin-4-one; With trifluoroacetic acid; In tetrahydrofuran; at 60 ℃; for 1h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In tetrahydrofuran; water; at 0 ℃; pH=8 - 9;

Reference yield: 96.0%

: 1403595-35-6
methyl 3-{[(2R,6R)-1-benzyl-2,6-dimethylpiperidin-4-yl]amino}-5-fluoro-2-methylbenzoate

: 75-07-0,9002-91-9
acetaldehyde

: 1403595-36-7
methyl 3-{[(2R,6R)-1-benzyl-2,6-dimethylpiperidin-4-yl](ethyl)amino}-5-fluoro-2-methylbenzoate

Guidance literature:: methyl 3-{[(2R,6R)-1-benzyl-2,6-dimethylpiperidin-4-yl]amino}-5-fluoro-2-methylbenzoate; acetaldehyde; With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 12h;

With sodium hydrogencarbonate; In dichloromethane; water; pH=8 - 9;

Reference yield:

: 1403595-35-6
methyl 3-{[(2R,6R)-1-benzyl-2,6-dimethylpiperidin-4-yl]amino}-5-fluoro-2-methylbenzoate

: 1403595-37-8
3-{[(2R,6R)-1-benzyl-2,6-dimethylpiperidin-4-yl](ethyl)amino}-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-5-fluoro-2-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 12 h / 20 °C

1.2: pH 8 - 9

2.1: sodium hydroxide; water / ethanol / 2 h / 80 °C

3.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 5 h / 23 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; dichloromethane; dimethyl sulfoxide;