4-oxo-4-((4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)amino)butanoic acid

Base Information

Chemical Name:4-oxo-4-((4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)amino)butanoic acid
CAS No.:1376446-80-8
Molecular Formula:C₁₄H₁₁F₃N₂O₃S
Molecular Weight:344.314
Hs Code.:

Synonyms:4-oxo-4-((4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)amino)butanoic acid

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Chemical Property of 4-oxo-4-((4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)amino)butanoic acid

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Technology Process of 4-oxo-4-((4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)amino)butanoic acid

There total 4 articles about 4-oxo-4-((4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)amino)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.2%

: 1398574-76-9
C₁₅H₁₃F₃N₂O₃S

: 1376446-80-8
4-oxo-4-((4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)amino)butanoic acid

Guidance literature:: C₁₅H₁₃F₃N₂O₃S; With sodium hydroxide; In 1,4-dioxane; at 60 ℃; for 2.5h;

With hydrogenchloride; In 1,4-dioxane; water;
DOI:10.1016/j.ejmech.2012.03.006

Reference yield:

: 709-63-7
1-(4-trifluoromethylphenyl)ethanone

: 1376446-80-8
4-oxo-4-((4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)amino)butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: copper(ll) bromide / ethanol; chloroform; ethyl acetate / 0.5 h / 65 °C

2: ethanol / 2 h / Reflux

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 24 h

4: sodium hydroxide / 1,4-dioxane / 2.5 h / 60 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; copper(ll) bromide; In 1,4-dioxane; ethanol; chloroform; ethyl acetate;
DOI:10.1016/j.ejmech.2012.03.006

Reference yield:

: 383-53-9
2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone

: 1376446-80-8
4-oxo-4-((4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)amino)butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 2 h / Reflux

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 24 h

3: sodium hydroxide / 1,4-dioxane / 2.5 h / 60 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In 1,4-dioxane; ethanol; chloroform;
DOI:10.1016/j.ejmech.2012.03.006