4-(4-Benzyloxycarbonylamino-2,6-difluorophenyl)-5,6-dihydro-2H-thiopyran

Base Information

• Chemical Name: 4-(4-Benzyloxycarbonylamino-2,6-difluorophenyl)-5,6-dihydro-2H-thiopyran
• CAS No.: 371195-42-5
• Molecular Formula: C₁₉H₁₇F₂NO₂S
• Molecular Weight: 361.412
• Mol file: 371195-42-5.mol

Synonyms:4-(4-Benzyloxycarbonylamino-2,6-difluorophenyl)-5,6-dihydro-2H-thiopyran

Chemical Property of 4-(4-Benzyloxycarbonylamino-2,6-difluorophenyl)-5,6-dihydro-2H-thiopyran

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-(4-Benzyloxycarbonylamino-2,6-difluorophenyl)-5,6-dihydro-2H-thiopyran

There total 1 articles about 4-(4-Benzyloxycarbonylamino-2,6-difluorophenyl)-5,6-dihydro-2H-thiopyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(3,6-dihydro-2H-thiopyran-4-yl)-3,5-difluorophenylamine (371195-41-4) + benzyl chloroformate (501-53-1,94274-21-2) → 4-(4-Benzyloxycarbonylamino-2,6-difluorophenyl)-5,6-dihydro-2H-thiopyran (371195-42-5)

Guidance literature:

With pyridine; In dichloromethane; at -20 - 20 ℃;

Reference yield:

4-(4-Benzyloxycarbonylamino-2,6-difluorophenyl)-5,6-dihydro-2H-thiopyran (371195-42-5) + (R)-glycidyl butyrate (60456-26-0) → (5R)-3-(3,5-difluoro-4-(2,6-dihydro-2H-thiopyran-4-yl)phenyl)-5-hydroxymethyloxazolidin-2-one (371195-43-6)

Guidance literature:

4-(4-Benzyloxycarbonylamino-2,6-difluorophenyl)-5,6-dihydro-2H-thiopyran; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 - -65 ℃; for 0.5h;

(R)-glycidyl butyrate; In tetrahydrofuran; hexanes; at -60 - 20 ℃;

upstream raw materials:

4-(3,6-dihydro-2H-thiopyran-4-yl)-3,5-difluorophenylamine

benzyl chloroformate

Downstream raw materials:

(5R)-3-(3,5-difluoro-4-(2,6-dihydro-2H-thiopyran-4-yl)phenyl)-5-hydroxymethyloxazolidin-2-one