[1-(2-Furylmethyl)piperidin-4-yl]methylamine

Base Information

• Chemical Name: [1-(2-Furylmethyl)piperidin-4-yl]methylamine
• CAS No.: 725211-89-2
• Molecular Formula: C₁₁H₁₈N₂O
• Molecular Weight: 194.277
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID50473503
• Wikidata: Q82302937
• Mol file: 725211-89-2.mol

Synonyms:725211-89-2;[1-(2-furylmethyl)piperidin-4-yl]methylamine;(1-(Furan-2-ylmethyl)piperidin-4-yl)methanamine;[1-(furan-2-ylmethyl)piperidin-4-yl]methanamine;1-{1-[(Furan-2-yl)methyl]piperidin-4-yl}methanamine;SCHEMBL4623772;DTXSID50473503;AKOS004123313;SB61210;LS-02140;1-(2-Furylmethyl)piperid-4-yl]methylamine;CS-0319505;FT-0679139;{[1-(2-furylmethyl)piperidin-4-yl]methyl}amine;F2187-0048

Chemical Property of [1-(2-Furylmethyl)piperidin-4-yl]methylamine

Chemical Property:

• Vapor Pressure: 0.00492mmHg at 25°C
• Refractive Index: 1.526
• Boiling Point: 276°C at 760 mmHg
• Flash Point: 120.7°C
• PSA: 42.40000
• Density: 1.059g/cm³
• LogP: 2.08850
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 194.141913202
• Heavy Atom Count: 14
• Complexity: 167

Purity/Quality:

98%min ^*data from raw suppliers

[1-(2-Furylmethyl)piperidin-4-yl]methylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCC1CN)CC2=CC=CO2
• Uses: 1-(2-Furanylmethyl)-4-piperidinemethanamine is used in the prepation of PRMT5 inhibitors.

Technology Process of [1-(2-Furylmethyl)piperidin-4-yl]methylamine

There total 3 articles about [1-(2-Furylmethyl)piperidin-4-yl]methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

tert-butyl ((1-(furan-2-ylmethyl)piperidin-4-yl)methyl)carbamate → ((1-(furan-2-ylmethyl)piperidin-4-yl)methyl)methanamine (725211-89-2)

Guidance literature:

With hydrogenchloride; In tert-butyl methyl ether; at 20 ℃;

Reference yield:

tert-butyl N-(4-piperidinylmethyl)carbamate (135632-53-0) → ((1-(furan-2-ylmethyl)piperidin-4-yl)methyl)methanamine (725211-89-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,2-dichloro-ethane / 1 h / 20 °C

1.2: 3 h

2.1: hydrogenchloride / tert-butyl methyl ether / 20 °C

With hydrogenchloride; In tert-butyl methyl ether; 1,2-dichloro-ethane;

Reference yield:

furfural (98-01-1) → ((1-(furan-2-ylmethyl)piperidin-4-yl)methyl)methanamine (725211-89-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,2-dichloro-ethane / 1 h / 20 °C

1.2: 3 h

2.1: hydrogenchloride / tert-butyl methyl ether / 20 °C

With hydrogenchloride; In tert-butyl methyl ether; 1,2-dichloro-ethane;

upstream raw materials:

tert-butyl N-(4-piperidinylmethyl)carbamate

furfural

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