methyl N-<4-prop-2-ynylamino>benzoyl>glycinate

Base Information

Chemical Name:methyl N-<4-prop-2-ynylamino>benzoyl>glycinate
CAS No.:101248-41-3
Molecular Formula:C₂₂H₂₁N₅O₄
Molecular Weight:419.44
Hs Code.:

methyl N-<4-<N-<(2-amino-4-hydroxy-6-quinazolinyl)methyl>prop-2-ynylamino>benzoyl>glycinate

Synonyms:methyl N-<4-prop-2-ynylamino>benzoyl>glycinate

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Chemical Property of methyl N-<4-prop-2-ynylamino>benzoyl>glycinate

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Technology Process of methyl N-<4-prop-2-ynylamino>benzoyl>glycinate

There total 3 articles about methyl N-<4-prop-2-ynylamino>benzoyl>glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 77766-62-2
2-amino-6-(bromomethyl)-4-hydroxyquinazoline hydrobromide

: 101248-39-9
methyl N-<4-(prop-2-ynylamino)benzoyl>glycinate

: 101248-41-3
methyl N-<4-prop-2-ynylamino>benzoyl>glycinate

Guidance literature:: With calcium carbonate; In various solvent(s); for 72h;
DOI:10.1021/jm00156a033

Reference yield:

: 61-78-9
p-Aminohippuric acid

: 101248-41-3
methyl N-<4-prop-2-ynylamino>benzoyl>glycinate

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / SOCl₂ / 22 h / -10 - 20 °C

2: 50.5 percent / K₂CO₃ / dimethylformamide; toluene / 3 h / 110 °C

3: 38 percent / CaCO₃ / various solvent(s) / 72 h

With thionyl chloride; potassium carbonate; calcium carbonate; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00156a033

Reference yield:

: 101248-38-8
methyl N-(4-aminobenzoyl)glycinate hydrochloride

: 101248-41-3
methyl N-<4-prop-2-ynylamino>benzoyl>glycinate

Guidance literature:: Multi-step reaction with 2 steps

1: 50.5 percent / K₂CO₃ / dimethylformamide; toluene / 3 h / 110 °C

2: 38 percent / CaCO₃ / various solvent(s) / 72 h

With potassium carbonate; calcium carbonate; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00156a033