2-amino-3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-propionamide

Base Information

Chemical Name:2-amino-3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-propionamide
CAS No.:225938-51-2
Molecular Formula:C₂₈H₄₄N₂O₅Si
Molecular Weight:516.753
Hs Code.:

2-amino-3-[5-(<i>tert</i>-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-<i>N</i>-(2-hydroxy-1-methyl-2-phenyl-ethyl)-<i>N</i>-methyl-propionamide

Synonyms:2-amino-3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-propionamide

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Chemical Property of 2-amino-3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-propionamide

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Technology Process of 2-amino-3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-propionamide

There total 3 articles about 2-amino-3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 170115-98-7
2-amino-N-((1R,2R)-1-hydroxy-1-phenylpropan-2-yl)-N-methylacetamide

: 225938-52-3
5-tert-butyldimethylsilyloxy-2,4-dimethoxy-3-methylbenzyl bromide

: 225938-51-2
2-amino-3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-propionamide

Guidance literature:: With lithium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield:

: 321-97-1,7009-81-6,90-83-5,6912-63-6
(1R,2R)-pseudoephedrine

: 225938-51-2
2-amino-3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 73.3 percent / LiOBu-t / tetrahydrofuran / 2 h / Ambient temperature

2: 1.) LiCl, LHMDS / 1.) THF, 0 deg C, 20 min, 2.) 0 deg C, 0.5 h

With lithium chloride; lithium hexamethyldisilazane; lithium tert-butoxide; In tetrahydrofuran;
DOI:10.1021/jo990341z

Reference yield:

: 170115-98-7
2-amino-N-((1R,2R)-1-hydroxy-1-phenylpropan-2-yl)-N-methylacetamide

: 225938-52-3
5-tert-butyldimethylsilyloxy-2,4-dimethoxy-3-methylbenzyl bromide

: 225938-51-2
2-amino-3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-propionamide

: 2-amino-3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-propionamide

Guidance literature:: With lithium chloride; lithium hexamethyldisilazane; Yield given; Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) THF, 0 deg C, 20 min, 2.) 0 deg C, 0.5 h;
DOI:10.1021/jo990341z