tert.-butyl (6R,7R)-7-benzoylamino-3-methoxy-8-oxo-5-oxa-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylate

Base Information

Chemical Name:tert.-butyl (6R,7R)-7-benzoylamino-3-methoxy-8-oxo-5-oxa-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylate
CAS No.:95967-31-0
Molecular Formula:C₁₉H₂₂N₂O₆
Molecular Weight:374.393
Hs Code.:

Synonyms:tert.-butyl (6R,7R)-7-benzoylamino-3-methoxy-8-oxo-5-oxa-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylate

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Chemical Property of tert.-butyl (6R,7R)-7-benzoylamino-3-methoxy-8-oxo-5-oxa-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylate

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Technology Process of tert.-butyl (6R,7R)-7-benzoylamino-3-methoxy-8-oxo-5-oxa-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylate

There total 8 articles about tert.-butyl (6R,7R)-7-benzoylamino-3-methoxy-8-oxo-5-oxa-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 95967-30-9
tert.-butyl (6R,7R)-7-benzoylamino-3-hydroxy-8-oxo-5-oxa-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylate

: 95967-31-0
tert.-butyl (6R,7R)-7-benzoylamino-3-methoxy-8-oxo-5-oxa-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylate

Guidance literature:: In diethyl ether; dichloromethane; Ambient temperature;
DOI:10.1016/S0040-4020(01)88797-4

Reference yield:

: 87064-89-9
tert.-butyl 4-hydroxyacetoacetate

: 95967-31-0
tert.-butyl (6R,7R)-7-benzoylamino-3-methoxy-8-oxo-5-oxa-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 31 percent / boron trifluoride etherate / tetrahydrofuran / 0.5 h / Ambient temperature

2: 96 percent / triethylamine, p-toluenesulfonyl azide / acetonitrile / 1.5 h / Ambient temperature

3: 82 percent / rhodium(II) acetate / benzene / 1 h / 80 °C

4: 72 percent / diethyl ether; CH₂Cl₂ / Ambient temperature

With 4-toluenesulfonyl azide; triethylamine; rhodium(II) acetate; boron trifluoride diethyl etherate; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile; benzene;
DOI:10.1016/S0040-4020(01)88797-4

Reference yield:

: 74530-56-6
tert-butyl 4-chloroacetoacetate

: 95967-31-0
tert.-butyl (6R,7R)-7-benzoylamino-3-methoxy-8-oxo-5-oxa-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) 80percent sodium hydride / 1.) THF, paraffin oil, 0 deg C, 1 h, RT, 0.5 h; 2.) THF, 0 deg C, 1 h, RT, 1 h

2: 97 percent / H₂ / 10percent palladium/C / methanol / 1.5 h / Ambient temperature

3: 31 percent / boron trifluoride etherate / tetrahydrofuran / 0.5 h / Ambient temperature

4: 96 percent / triethylamine, p-toluenesulfonyl azide / acetonitrile / 1.5 h / Ambient temperature

5: 82 percent / rhodium(II) acetate / benzene / 1 h / 80 °C

6: 72 percent / diethyl ether; CH₂Cl₂ / Ambient temperature

With 4-toluenesulfonyl azide; hydrogen; sodium hydride; triethylamine; rhodium(II) acetate; palladium on activated charcoal; boron trifluoride diethyl etherate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetonitrile; benzene;
DOI:10.1016/S0040-4020(01)88797-4