(R)-2-(2,4-difluorophenyl)-5-(11-fluoro-6-((3-fluoropyrrolidin-1-yl)methyl)pyrido[3',2':4,5]pyrimido [1,6-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Base Information

Chemical Name:(R)-2-(2,4-difluorophenyl)-5-(11-fluoro-6-((3-fluoropyrrolidin-1-yl)methyl)pyrido[3',2':4,5]pyrimido [1,6-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide
CAS No.:1621887-35-1
Molecular Formula:C₃₇H₃₀F₄N₆O₄S
Molecular Weight:730.743
Hs Code.:

(R)-2-(2,4-difluorophenyl)-5-(11-fluoro-6-((3-fluoropyrrolidin-1-yl)methyl)pyrido[3',2':4,5]pyrimido [1,6-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Synonyms:(R)-2-(2,4-difluorophenyl)-5-(11-fluoro-6-((3-fluoropyrrolidin-1-yl)methyl)pyrido[3',2':4,5]pyrimido [1,6-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Chemical Property of (R)-2-(2,4-difluorophenyl)-5-(11-fluoro-6-((3-fluoropyrrolidin-1-yl)methyl)pyrido[3',2':4,5]pyrimido [1,6-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Technology Process of (R)-2-(2,4-difluorophenyl)-5-(11-fluoro-6-((3-fluoropyrrolidin-1-yl)methyl)pyrido[3',2':4,5]pyrimido [1,6-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

There total 20 articles about (R)-2-(2,4-difluorophenyl)-5-(11-fluoro-6-((3-fluoropyrrolidin-1-yl)methyl)pyrido[3',2':4,5]pyrimido [1,6-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1621888-74-1
5-(6-(chloromethyl)-11-fluoropyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(2,4-difluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

: 679431-51-7,116574-74-4
(3R)-3-fluoropyrrolidine

: 1621887-35-1
(R)-2-(2,4-difluorophenyl)-5-(11-fluoro-6-((3-fluoropyrrolidin-1-yl)methyl)pyrido[3',2':4,5]pyrimido [1,6-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 60 ℃; for 2h; Inert atmosphere;

Reference yield:

: 400777-06-2
6-chloro-2-iodopyridin-3-amine

: 1621887-35-1
(R)-2-(2,4-difluorophenyl)-5-(11-fluoro-6-((3-fluoropyrrolidin-1-yl)methyl)pyrido[3',2':4,5]pyrimido [1,6-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; caesium carbonate / 1,4-dioxane / 16 h / 70 °C / Inert atmosphere

2: palladium diacetate; tricyclohexylphosphine; potassium phosphate tribasic trihydrate / isopropyl alcohol / 8 h / 90 °C / Inert atmosphere

3: acetic acid / 70 °C / Inert atmosphere

4: triethylamine / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere

With dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; potassium phosphate tribasic trihydrate; palladium diacetate; caesium carbonate; acetic acid; triethylamine; tricyclohexylphosphine; In 1,4-dioxane; N,N-dimethyl-formamide; isopropyl alcohol; 1: |Suzuki Coupling / 2: |Suzuki Coupling;

Reference yield:

: 1432061-90-9
ethyl 6-amino-5-bromobenzofuran-3-carboxylate

: 1621887-35-1
(R)-2-(2,4-difluorophenyl)-5-(11-fluoro-6-((3-fluoropyrrolidin-1-yl)methyl)pyrido[3',2':4,5]pyrimido [1,6-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 2 h / Reflux

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 2 h

3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 °C

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic trihydrate / N,N-dimethyl-formamide / 3 h / 15 °C / Inert atmosphere

5.1: pyridine / dichloromethane / 0 - 20 °C

5.2: 1 h / 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

7.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / water; 1,4-dioxane / 3 h / 130 °C

8.1: palladium diacetate; tricyclohexylphosphine; potassium phosphate tribasic trihydrate / isopropyl alcohol / 8 h / 90 °C / Inert atmosphere

9.1: acetic acid / 70 °C / Inert atmosphere

10.1: triethylamine / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide monohydrate; potassium phosphate tribasic trihydrate; water; potassium acetate; palladium diacetate; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium diisopropyl amide; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; 4.1: |Suzuki Coupling / 8.1: |Suzuki Coupling;