diethyl 3,3'-[(3,4-dimethoxyphenyl)methylene]bis(4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate)

Base Information

• Chemical Name: diethyl 3,3'-[(3,4-dimethoxyphenyl)methylene]bis(4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate)
• CAS No.: 1379996-99-2
• Molecular Formula: C₃₁H₃₈N₂O₆
• Molecular Weight: 534.653
• Mol file: 1379996-99-2.mol

Synonyms:diethyl 3,3'-[(3,4-dimethoxyphenyl)methylene]bis(4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate)

Chemical Property of diethyl 3,3'-[(3,4-dimethoxyphenyl)methylene]bis(4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 3,3'-[(3,4-dimethoxyphenyl)methylene]bis(4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate)

There total 1 articles about diethyl 3,3'-[(3,4-dimethoxyphenyl)methylene]bis(4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethyl 4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate (65880-17-3) + 3,4-dimethoxy-benzaldehyde (120-14-9) → diethyl 3,3'-[(3,4-dimethoxyphenyl)methylene]bis(4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate) (1379996-99-2)

Guidance literature:

With boron trifluoride diethyl etherate; tetrabutyl-ammonium chloride; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1002/ejoc.201101729

Reference yield: 97.0%

diethyl 3,3'-[(3,4-dimethoxyphenyl)methylene]bis(4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate) (1379996-99-2) → ethyl (1Z)-1-{(3,4-dimethoxyphenyl)[3-(ethoxycarbonyl)-4,5,6,7-tetrahydro-2H-isoindol-1-yl]methylene}-4,5,6,7-tetrahydro-1H-isoindole-3-carboxylate (1379997-04-2)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/ejoc.201101729

Reference yield:

diethyl 3,3'-[(3,4-dimethoxyphenyl)methylene]bis(4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate) (1379996-99-2) → C31H36N2O6

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran;

DOI:10.1134/S1070428014020158

upstream raw materials:

ethyl 4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate

3,4-dimethoxy-benzaldehyde

Downstream raw materials:

ethyl (1Z)-1-{(3,4-dimethoxyphenyl)[3-(ethoxycarbonyl)-4,5,6,7-tetrahydro-2H-isoindol-1-yl]methylene}-4,5,6,7-tetrahydro-1H-isoindole-3-carboxylate

C₂₀H₂₃NO₅