2-(4-bromo-2,6-difluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetamide

Base Information

Chemical Name:2-(4-bromo-2,6-difluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetamide
CAS No.:1426050-99-8
Molecular Formula:C₁₉H₂₂BrF₂N₃O₃
Molecular Weight:458.303
Hs Code.:

Synonyms:2-(4-bromo-2,6-difluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetamide

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Chemical Property of 2-(4-bromo-2,6-difluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetamide

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Technology Process of 2-(4-bromo-2,6-difluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetamide

There total 6 articles about 2-(4-bromo-2,6-difluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1375107-47-3
4-cyclopropyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one hydrochloride

: 1426050-93-2
2-(4-bromo-2,6-difluorophenyl)-2-hydroxyacetamide

: 1426050-99-8
2-(4-bromo-2,6-difluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetamide

Guidance literature:: 2-(4-bromo-2,6-difluorophenyl)-2-hydroxyacetamide; With methanesulfonyl chloride; triethylamine; In acetonitrile; at 40 ℃; for 3h;

4-cyclopropyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one hydrochloride; In acetonitrile; at 90 ℃; for 3h;

Reference yield:

: 1375107-45-1
1,1-dimethylethyl-4-{[(chloroacetyl)(cyclopropyl)amino]methyl}-4-hydroxy-1-piperidine carboxylate

: 1426050-99-8
2-(4-bromo-2,6-difluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; sodium hydroxide / tetrahydrofuran; water

2.1: hydrogenchloride; ethanol / 1,4-dioxane / 20 °C / Cooling with ice

3.1: methanesulfonyl chloride; triethylamine / acetonitrile / 3 h / 40 °C

3.2: 3 h / 90 °C

With hydrogenchloride; ethanol; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; methanesulfonyl chloride; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile;

Reference yield:

: 1375107-46-2
1,1-dimethylethyl 4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

: 1426050-99-8
2-(4-bromo-2,6-difluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; ethanol / 1,4-dioxane / 20 °C / Cooling with ice

2.1: methanesulfonyl chloride; triethylamine / acetonitrile / 3 h / 40 °C

2.2: 3 h / 90 °C

With hydrogenchloride; ethanol; methanesulfonyl chloride; triethylamine; In 1,4-dioxane; acetonitrile;