diethyl (acetylamino)<<4-(diethoxyphosphinyl)phenyl>methyl>propanedioate

Base Information

• Chemical Name: diethyl (acetylamino)<<4-(diethoxyphosphinyl)phenyl>methyl>propanedioate
• CAS No.: 120667-47-2
• Molecular Formula: C₂₀H₃₀NO₈P
• Molecular Weight: 443.434
• Mol file: 120667-47-2.mol

Synonyms:diethyl (acetylamino)<<4-(diethoxyphosphinyl)phenyl>methyl>propanedioate

Chemical Property of diethyl (acetylamino)<<4-(diethoxyphosphinyl)phenyl>methyl>propanedioate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of diethyl (acetylamino)<<4-(diethoxyphosphinyl)phenyl>methyl>propanedioate

There total 3 articles about diethyl (acetylamino)<<4-(diethoxyphosphinyl)phenyl>methyl>propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

diethyl (acetylamino)<(4-bromophenyl)methyl>propanedioate (71078-92-7) + phosphonic acid diethyl ester (762-04-9) → diethyl (acetylamino)<<4-(diethoxyphosphinyl)phenyl>methyl>propanedioate (120667-47-2)

Guidance literature:

With triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 90 ℃; for 24h;

DOI:10.1021/jm00127a030

Reference yield:

2-acetylaminomalonic acid diethyl ester (1068-90-2) → diethyl (acetylamino)<<4-(diethoxyphosphinyl)phenyl>methyl>propanedioate (120667-47-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaOEt / 1.) EtOH, 15 min, 2.) THF, RT, overnight

2: 98 percent / triethylamine, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / toluene / 24 h / 90 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium ethanolate; triethylamine; In toluene;

DOI:10.1021/jm00127a030

Reference yield:

1-bromomethyl-4-bromobenzene (589-15-1) → diethyl (acetylamino)<<4-(diethoxyphosphinyl)phenyl>methyl>propanedioate (120667-47-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaOEt / 1.) EtOH, 15 min, 2.) THF, RT, overnight

2: 98 percent / triethylamine, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / toluene / 24 h / 90 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium ethanolate; triethylamine; In toluene;

DOI:10.1021/jm00127a030

upstream raw materials:

diethyl (acetylamino)<(4-bromophenyl)methyl>propanedioate

phosphonic acid diethyl ester

1-bromomethyl-4-bromobenzene

2-acetylaminomalonic acid diethyl ester

Downstream raw materials:

4-Phosphono-DL-phenylalanine