1-cyclopropylmethyl-4-(4-phenoxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester

Base Information

• Chemical Name: 1-cyclopropylmethyl-4-(4-phenoxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester
• CAS No.: 226397-23-5
• Molecular Formula: C₂₄H₂₉NO₅S
• Molecular Weight: 443.564
• Mol file: 226397-23-5.mol

Synonyms:1-cyclopropylmethyl-4-(4-phenoxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester

Chemical Property of 1-cyclopropylmethyl-4-(4-phenoxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-cyclopropylmethyl-4-(4-phenoxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester

There total 5 articles about 1-cyclopropylmethyl-4-(4-phenoxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

ethyl 4-[(4-phenoxyphenyl)sulfonyl]piperidine-4-carboxylate hydrochloride + cyclopropylcarbinyl bromide (7051-34-5) → 1-cyclopropylmethyl-4-(4-phenoxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester (226397-23-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1021/jm0500875

Reference yield:

1-tert-butyl 4-ethyl 4-[(4-phenoxyphenyl)thio]piperidine-1,4-dicarboxylate (226396-40-3) → 1-cyclopropylmethyl-4-(4-phenoxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester (226397-23-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 1.5 h / 0 - 20 °C

2: 100 percent / HCl(gas) / ethyl acetate / 0.08 h

3: 91 percent / K₂CO₃ / dimethylformamide / 16 h / 20 °C

With hydrogenchloride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm0500875

Reference yield:

1-tert-butyl 4-ethyl 4-[(4-phenoxyphenyl)sulfonyl]piperidine-1,4-dicarboxylate (226396-42-5) → 1-cyclopropylmethyl-4-(4-phenoxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester (226397-23-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / HCl(gas) / ethyl acetate / 0.08 h

2: 91 percent / K₂CO₃ / dimethylformamide / 16 h / 20 °C

With hydrogenchloride; potassium carbonate; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm0500875

upstream raw materials:

cyclopropylcarbinyl bromide

1-tert-butyl 4-ethyl 4-[(4-phenoxyphenyl)thio]piperidine-1,4-dicarboxylate

1-tert-butyl 4-ethyl 4-[(4-phenoxyphenyl)sulfonyl]piperidine-1,4-dicarboxylate

1,2-bis(4-phenoxyphenyl)disulfane

Downstream raw materials:

1-cyclopropylmethyl-4-(4-phenoxy-benzenesulfonyl)-piperidine-4-carboxylic acid