Chemical Property of Psora-4
Chemical Property:
- Vapor Pressure:1.24E-11mmHg at 25°C
- Melting Point:98 °C(Solv: methanol (67-56-1); water (7732-18-5))
- Refractive Index:1.626
- Boiling Point:537.7°C at 760 mmHg
- Flash Point:279°C
- PSA：52.58000
- Density:1.246g/cm3
- LogP:4.94090
- Storage Temp.:2-8°C
- Solubility.:DMSO: soluble10mg/mL, clear
- XLogP3:5
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:6
- Exact Mass:334.12050905
- Heavy Atom Count:25
- Complexity:482
- Purity/Quality:
-
98%,99%, *data from raw suppliers
Psora4 *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26-36
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC=C(C=C1)CCCCOC2=C3C=CC(=O)OC3=CC4=C2C=CO4
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Description
Psora 4 is an inhibitor of voltage-gated potassium channels (Kv1.3; EC50 = 3 nM). It is selective for Kv1.3 over Kv1.1, Kv1.2, Kv1.4, Kv1.7, and Kv3.1 channels (EC50s = 62, 49, 202, 100, and 1,500 nM, respectively) but does inhibit the Kv1.5 channel (EC50 = 7.7 nM). Psora 4 selectively binds to the C-type inactivated state of the Kv1.3 channel and inhibits potassium current in a use-dependent manner. It has immunosuppressive activity, inhibiting proliferation of human and rat myelin-specific effector memory T cells in vitro (TEM cells; EC50s = 25 and 60 nM, respectively).
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Uses
Psora-4 is the most potent small-molecule Kv1.3 blocker known. Psora-4 and other Kv1.3 blockers may be useful as immunomodulators for the therapy of autoimmune disorders.
