5H-1,4-Dioxepino[5,6-c]pyridine-6-methanol,3-ethyl-2,3-dihydro-9-methyl-(9CI)

Base Information

Chemical Name:5H-1,4-Dioxepino[5,6-c]pyridine-6-methanol,3-ethyl-2,3-dihydro-9-methyl-(9CI)
CAS No.:724696-70-2
Molecular Formula:C₁₂H₁₇NO₃
Molecular Weight:223.272
Hs Code.:
Mol file:724696-70-2.mol

Synonyms:5H-1,4-Dioxepino[5,6-c]pyridine-6-methanol,3-ethyl-2,3-dihydro-9-methyl-(9CI)

Suppliers and Price of 5H-1,4-Dioxepino[5,6-c]pyridine-6-methanol,3-ethyl-2,3-dihydro-9-methyl-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5H-1,4-Dioxepino[5,6-c]pyridine-6-methanol,3-ethyl-2,3-dihydro-9-methyl-(9CI)

Chemical Property:

PSA：51.58000
LogP:1.56990

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5H-1,4-Dioxepino[5,6-c]pyridine-6-methanol,3-ethyl-2,3-dihydro-9-methyl-(9CI)

There total 3 articles about 5H-1,4-Dioxepino[5,6-c]pyridine-6-methanol,3-ethyl-2,3-dihydro-9-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 65-23-6
5-hydroxy-6-methyl-3,4-pyridinedimethanol

: 724696-70-2
3-ethyl-2,3-dihydro-6-hydroxymethyl-9-methyl-5H<1,4>-dioxepino<5,6-c>pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaOEt 2.) KI / 2.) reflux, 10h, acetone

2: 74 percent / CF₃SO₃H-H₂O (1:5) / acetonitrile / 1.5 h / Heating

3: 1.) NiCl₂*6H₂O 2.) NaBH₄ / 1.) MeOH-THF (1:9) 2.) 5 min, 0 deg C

With sodium tetrahydroborate; trifluorormethanesulfonic acid; sodium ethanolate; potassium iodide; nickel dichloride; In acetonitrile;
DOI:10.1248/cpb.38.19

Reference yield:

: 128175-29-1
3-(2-butenyloxy)-4,5-bis(hydroxymethyl)-2-methylpyridine

: 724696-70-2
3-ethyl-2,3-dihydro-6-hydroxymethyl-9-methyl-5H<1,4>-dioxepino<5,6-c>pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / CF₃SO₃H-H₂O (1:5) / acetonitrile / 1.5 h / Heating

2: 1.) NiCl₂*6H₂O 2.) NaBH₄ / 1.) MeOH-THF (1:9) 2.) 5 min, 0 deg C

With sodium tetrahydroborate; trifluorormethanesulfonic acid; nickel dichloride; In acetonitrile;
DOI:10.1248/cpb.38.19

Reference yield:

: 128175-32-6
2,3-dihydro-6-hydroxymethyl-9-methyl-3-<1-(phenylseleno)ethyl>-5H<1,4>-dioxepino<5,6-c>pyridine

: 724696-70-2
3-ethyl-2,3-dihydro-6-hydroxymethyl-9-methyl-5H<1,4>-dioxepino<5,6-c>pyridine

Guidance literature:: With sodium tetrahydroborate; nickel dichloride; Yield given. Multistep reaction; 1.) MeOH-THF (1:9) 2.) 5 min, 0 deg C;
DOI:10.1248/cpb.38.19