6-trifluoromethyl-4-oxo-4H-1,3-dioxine-2-spirocyclohexane

Base Information

• Chemical Name: 6-trifluoromethyl-4-oxo-4H-1,3-dioxine-2-spirocyclohexane
• CAS No.: 144765-05-9
• Molecular Formula: C₁₀H₁₁F₃O₃
• Molecular Weight: 236.191
• Mol file: 144765-05-9.mol

Synonyms:6-trifluoromethyl-4-oxo-4H-1,3-dioxine-2-spirocyclohexane

Chemical Property of 6-trifluoromethyl-4-oxo-4H-1,3-dioxine-2-spirocyclohexane

Chemical Property:

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Technology Process of 6-trifluoromethyl-4-oxo-4H-1,3-dioxine-2-spirocyclohexane

There total 1 articles about 6-trifluoromethyl-4-oxo-4H-1,3-dioxine-2-spirocyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trifluoroacetylacetic acid (400-36-2) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 6-trifluoromethyl-4-oxo-4H-1,3-dioxine-2-spirocyclohexane (144765-05-9)

Guidance literature:

With sulfuric acid; acetic anhydride; sodium hydrogencarbonate; Yield given. Multistep reaction; 1) < 5 deg C, 19 h, 2) ice cooling, 30 min;

DOI:10.1055/s-1992-26283

upstream raw materials:

trifluoroacetylacetic acid

cyclohexanone

Refernces