N-(7-(3-(benzyloxy)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-4-(2-hydroxypropan-2-yl)benzamide

Base Information

Chemical Name:N-(7-(3-(benzyloxy)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-4-(2-hydroxypropan-2-yl)benzamide
CAS No.:1190045-46-5
Molecular Formula:C₂₉H₂₆N₄O₃
Molecular Weight:478.55
Hs Code.:

Synonyms:N-(7-(3-(benzyloxy)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-4-(2-hydroxypropan-2-yl)benzamide

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Chemical Property of N-(7-(3-(benzyloxy)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-4-(2-hydroxypropan-2-yl)benzamide

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Technology Process of N-(7-(3-(benzyloxy)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-4-(2-hydroxypropan-2-yl)benzamide

There total 5 articles about N-(7-(3-(benzyloxy)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-4-(2-hydroxypropan-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1189852-14-9
N-(7-chloropyrazolo[1,5-a]pyrimidin-5-yl)-4-(2-hydroxypropan-2-yl)benzamide

: 156682-54-1
3-(benzyloxy)phenylboronic acid

: 1190045-46-5
N-(7-(3-(benzyloxy)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-4-(2-hydroxypropan-2-yl)benzamide

Guidance literature:: With sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 110 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 1189852-04-7
7-chloropyrazolo[1,5-a]pyrimidin-5-amine

: 1190045-46-5
N-(7-(3-(benzyloxy)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-4-(2-hydroxypropan-2-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 0 °C

2.1: tetrahydrofuran; diethyl ether / 0 °C

2.2: 0 °C

3.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.33 h / 110 °C / Microwave irradiation

With pyridine; sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water;

Reference yield:

: 1189852-00-3
C₆H₄Cl₃N₄OP

: 1190045-46-5
N-(7-(3-(benzyloxy)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-4-(2-hydroxypropan-2-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; water / 0 - 20 °C / Inert atmosphere

1.2: 0 °C / pH 9

2.1: pyridine / 0 °C

3.1: tetrahydrofuran; diethyl ether / 0 °C

3.2: 0 °C

4.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.33 h / 110 °C / Microwave irradiation

With pyridine; hydrogenchloride; water; sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water;