2-(4-(tert-butyl)phenyl)cyclopentanone

Base Information

• Chemical Name: 2-(4-(tert-butyl)phenyl)cyclopentanone
• CAS No.: 115614-49-8
• Molecular Formula: C₁₅H₂₀O
• Molecular Weight: 216.323
• Mol file: 115614-49-8.mol

Synonyms:2-(4-(tert-butyl)phenyl)cyclopentanone

Chemical Property of 2-(4-(tert-butyl)phenyl)cyclopentanone

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(tert-butyl)phenyl)cyclopentanone

There total 4 articles about 2-(4-(tert-butyl)phenyl)cyclopentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1-bromo-4-tert-butylbenzene (3972-65-4) + cyclopentanone (120-92-3) → 2-(4-(tert-butyl)phenyl)cyclopentanone (115614-49-8)

Guidance literature:

With pyrrolidine; tert-Octylamine; sodium acetate; palladium diacetate; tris-(o-tolyl)phosphine; In 1,4-dioxane; at 110 ℃; for 12h; chemoselective reaction; Inert atmosphere; Sealed tube; Glovebox;

DOI:10.1002/anie.201510638

Reference yield: 35.0%

(+/-) trans-2-(4-tert-butyl-phenyl)-cyclopentanol → 2-(4-(tert-butyl)phenyl)cyclopentanone (115614-49-8)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 48h;

Reference yield:

1-bromo-4-tert-butylbenzene (3972-65-4) → 2-(4-(tert-butyl)phenyl)cyclopentanone (115614-49-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium / diethyl ether / 2 h

1.2: 4 h / 20 °C

2.1: pyridinium chlorochromate / dichloromethane / 48 h / 20 °C

With lithium; pyridinium chlorochromate; In diethyl ether; dichloromethane;

upstream raw materials:

1-bromo-4-tert-butylbenzene

cyclopentanone

Cyclopentene oxide