4-[(2R,3R,4R,5R)-2-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-ylsulfanylmethyl]-heptanedioic acid dibenzyl ester

Base Information

Chemical Name:4-[(2R,3R,4R,5R)-2-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-ylsulfanylmethyl]-heptanedioic acid dibenzyl ester
CAS No.:607390-50-1
Molecular Formula:C₃₁H₃₆N₂O₉S
Molecular Weight:612.701
Hs Code.:

4-[(2R,3R,4R,5R)-2-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-ylsulfanylmethyl]-heptanedioic acid dibenzyl ester

Synonyms:4-[(2R,3R,4R,5R)-2-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-ylsulfanylmethyl]-heptanedioic acid dibenzyl ester

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Chemical Property of 4-[(2R,3R,4R,5R)-2-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-ylsulfanylmethyl]-heptanedioic acid dibenzyl ester

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Technology Process of 4-[(2R,3R,4R,5R)-2-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-ylsulfanylmethyl]-heptanedioic acid dibenzyl ester

There total 2 articles about 4-[(2R,3R,4R,5R)-2-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-ylsulfanylmethyl]-heptanedioic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31281-28-4
2'-mercapto-2'-deoxyuridine

: 607390-63-6
Dibenzyl-4-(iodomethyl)heptanedioate

: 607390-50-1
4-[(2R,3R,4R,5R)-2-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-ylsulfanylmethyl]-heptanedioic acid dibenzyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 16h;
DOI:10.1021/ja035186r

Reference yield:

: 83088-00-0
2'-deoxy-2'-(4-methoxyphenylmethanethio)uridine

: 607390-50-1
4-[(2R,3R,4R,5R)-2-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-ylsulfanylmethyl]-heptanedioic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: TFA; phenol / 2 h / Heating

2: DIEA / acetonitrile / 16 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; phenol; In acetonitrile;
DOI:10.1021/ja035186r

Reference yield:

: 607390-50-1
4-[(2R,3R,4R,5R)-2-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-ylsulfanylmethyl]-heptanedioic acid dibenzyl ester

: 4-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-ylsulfanylmethyl]-heptanedioic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 2 h / 20 °C

2: DMAP; Et₃N / CH₂Cl₂ / 0.5 h

With pyridine; dmap; triethylamine; In dichloromethane;
DOI:10.1021/ja035186r