1',3'-dimethyl-3-phenyl-3,4-dihydro-1H,1'H-spiro[naphthalene-2,5'-pyrimidine]-2',4',6'(3'H)-trione

Base Information

Chemical Name:1',3'-dimethyl-3-phenyl-3,4-dihydro-1H,1'H-spiro[naphthalene-2,5'-pyrimidine]-2',4',6'(3'H)-trione
CAS No.:1268267-86-2
Molecular Formula:C₂₁H₂₀N₂O₃
Molecular Weight:348.401
Hs Code.:

Synonyms:1',3'-dimethyl-3-phenyl-3,4-dihydro-1H,1'H-spiro[naphthalene-2,5'-pyrimidine]-2',4',6'(3'H)-trione

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Chemical Property of 1',3'-dimethyl-3-phenyl-3,4-dihydro-1H,1'H-spiro[naphthalene-2,5'-pyrimidine]-2',4',6'(3'H)-trione

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Technology Process of 1',3'-dimethyl-3-phenyl-3,4-dihydro-1H,1'H-spiro[naphthalene-2,5'-pyrimidine]-2',4',6'(3'H)-trione

There total 4 articles about 1',3'-dimethyl-3-phenyl-3,4-dihydro-1H,1'H-spiro[naphthalene-2,5'-pyrimidine]-2',4',6'(3'H)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1268267-70-4
1,3-dimethyl-5-(2-phenethylbenzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione

: 1268267-86-2
1',3'-dimethyl-3-phenyl-3,4-dihydro-1H,1'H-spiro[naphthalene-2,5'-pyrimidine]-2',4',6'(3'H)-trione

Guidance literature:: With scandium tris(trifluoromethanesulfonate); In 1,2-dichloro-ethane; for 24h; Reflux;
DOI:10.1021/ja110520p

Reference yield:

: 32832-96-5
2-phenethylbenzaldehyde

: 1268267-86-2
1',3'-dimethyl-3-phenyl-3,4-dihydro-1H,1'H-spiro[naphthalene-2,5'-pyrimidine]-2',4',6'(3'H)-trione

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine; acetic acid / benzene / 16 h / 60 °C

2: scandium tris(trifluoromethanesulfonate) / 1,2-dichloro-ethane / 24 h / Reflux

With piperidine; acetic acid; scandium tris(trifluoromethanesulfonate); In 1,2-dichloro-ethane; benzene;
DOI:10.1021/ja110520p

Reference yield:

: 4890-85-1
o-phenethylbenzoic acid

: 1268267-86-2
1',3'-dimethyl-3-phenyl-3,4-dihydro-1H,1'H-spiro[naphthalene-2,5'-pyrimidine]-2',4',6'(3'H)-trione

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / diethyl ether / 3.42 h / 0 - 20 °C

2: manganese(IV) oxide / dichloromethane / 16 h / Reflux

3: piperidine; acetic acid / benzene / 16 h / 60 °C

4: scandium tris(trifluoromethanesulfonate) / 1,2-dichloro-ethane / 24 h / Reflux

With piperidine; manganese(IV) oxide; lithium aluminium tetrahydride; acetic acid; scandium tris(trifluoromethanesulfonate); In diethyl ether; dichloromethane; 1,2-dichloro-ethane; benzene;
DOI:10.1021/ja110520p