azepin-10-yl]methyl-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: azepin-10-yl]methyl-, 1,1-dimethylethyl ester
• CAS No.: 724446-08-6
• Molecular Formula: C23H29 F N4 O5
• Molecular Weight: 460.505
• Mol file: 724446-08-6.mol

Synonyms:Carbamicacid,[2-[[[(4-fluorophenyl)methyl]amino]carbonyl]-4,6,7,8,9,10-hexahydro-3-hydroxy-4-oxopyrimido[1,2-a]azepin-10-yl]methyl-,1,1-dimethylethyl ester (9CI)

Chemical Property of azepin-10-yl]methyl-, 1,1-dimethylethyl ester

Chemical Property:

• PSA: 117.25000
• LogP: 3.68470

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of azepin-10-yl]methyl-, 1,1-dimethylethyl ester

There total 2 articles about azepin-10-yl]methyl-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

C18H27N3O8S (724446-04-2) + para-fluorobenzylamine (140-75-0) → C23H29FN4O5 (724446-08-6)

Guidance literature:

In ethanol; for 8h; Heating / reflux;

Reference yield:

C27H39FN4O14S4 → C23H29FN4O5 (724446-08-6)

Guidance literature:

C₂₇H₃₉FN₄O₁₄S₄; With sodium hydroxide; In ISOPROPYLAMIDE; water; at 78 - 82 ℃; for 24h; large scale;

With hydrogenchloride; In ISOPROPYLAMIDE; water; at 50 ℃; for 2h; pH=2.0 - 2.5; Product distribution / selectivity;

Reference yield: 99.0%

C23H29FN4O5 (724446-08-6) → C18H21FN4O3*ClH

Guidance literature:

With hydrogenchloride; In ethyl acetate; at -30 - 25 ℃; for 13.5h; Product distribution / selectivity; large scale;

upstream raw materials:

C₁₈H₂₇N₃O₈S

para-fluorobenzylamine

Refernces