Technology Process of 4,4-dimethyl-3-phenyltetrahydro-2H-pyran
There total 4 articles about 4,4-dimethyl-3-phenyltetrahydro-2H-pyran which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2-phenylmalononitrile; 9-(2-mesityl)-10-methylacridinium perchlorate;
In
dichloromethane;
at 23 ℃;
for 72h;
regioselective reaction;
Schlenk technique;
Irradiation;
DOI:10.1021/ja309635w
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium hydroxide; lithium aluminium tetrahydride / tetrahydrofuran; water / 0.17 h / 0 - 25 °C / Inert atmosphere
2: 9-(2-mesityl)-10-methylacridinium perchlorate; 2-phenylmalononitrile / dichloromethane / 72 h / 23 °C / Schlenk technique; Irradiation
With
lithium aluminium tetrahydride; 2-phenylmalononitrile; sodium hydroxide; 9-(2-mesityl)-10-methylacridinium perchlorate;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ja309635w
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sulfuric acid; acetic acid; potassium permanganate / dichloromethane / Cooling with ice
1.2: Inert atmosphere
2.1: sodium hydroxide; lithium aluminium tetrahydride / tetrahydrofuran; water / 0.17 h / 0 - 25 °C / Inert atmosphere
3.1: 9-(2-mesityl)-10-methylacridinium perchlorate; 2-phenylmalononitrile / dichloromethane / 72 h / 23 °C / Schlenk technique; Irradiation
With
potassium permanganate; lithium aluminium tetrahydride; sulfuric acid; 2-phenylmalononitrile; acetic acid; sodium hydroxide; 9-(2-mesityl)-10-methylacridinium perchlorate;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ja309635w
