Technology Process of 3-(2,2-dibromo-1-ethylcyclopropyl)propyl toluene-4-sulfonate
There total 4 articles about 3-(2,2-dibromo-1-ethylcyclopropyl)propyl toluene-4-sulfonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride;
In
benzene;
at 0 - 18 ℃;
for 16h;
DOI:10.1039/b209992f
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 95 percent / aq. NaHCO3; K2CO3; Oxone / acetone / 29 h / 18 °C
2.1: NaHMDS / tetrahydrofuran / 1.5 h / 18 °C
2.2: 30 percent / tetrahydrofuran / 15 h / 18 °C
3.1: 57 percent / LiAlH4 / diethyl ether / 1.5 h
4.1: Et3N; DMAP / CH2Cl2 / 48 h / 4 °C
5.1: 70 percent / aq. NaOH; benzyltriethylammonium chloride / benzene / 16 h / 0 - 18 °C
With
dmap; Oxone; sodium hydroxide; lithium aluminium tetrahydride; N-benzyl-N,N,N-triethylammonium chloride; sodium hexamethyldisilazane; sodium hydrogencarbonate; potassium carbonate; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; acetone; benzene;
1.1: Nef reaction / 2.2: Wittig reaction;
DOI:10.1039/b209992f
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: NaHMDS / tetrahydrofuran / 1.5 h / 18 °C
1.2: 30 percent / tetrahydrofuran / 15 h / 18 °C
2.1: 57 percent / LiAlH4 / diethyl ether / 1.5 h
3.1: Et3N; DMAP / CH2Cl2 / 48 h / 4 °C
4.1: 70 percent / aq. NaOH; benzyltriethylammonium chloride / benzene / 16 h / 0 - 18 °C
With
dmap; sodium hydroxide; lithium aluminium tetrahydride; N-benzyl-N,N,N-triethylammonium chloride; sodium hexamethyldisilazane; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; benzene;
1.2: Wittig reaction;
DOI:10.1039/b209992f
