(E)-2-(2-ethylbenzyl)-3-oxo-3-(4-phenylcyclohexyl)-propionic acid ethyl ester

Base Information

Chemical Name:(E)-2-(2-ethylbenzyl)-3-oxo-3-(4-phenylcyclohexyl)-propionic acid ethyl ester
CAS No.:1400902-37-5
Molecular Formula:C₂₆H₃₂O₃
Molecular Weight:392.538
Hs Code.:

Synonyms:(E)-2-(2-ethylbenzyl)-3-oxo-3-(4-phenylcyclohexyl)-propionic acid ethyl ester

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Chemical Property of (E)-2-(2-ethylbenzyl)-3-oxo-3-(4-phenylcyclohexyl)-propionic acid ethyl ester

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Technology Process of (E)-2-(2-ethylbenzyl)-3-oxo-3-(4-phenylcyclohexyl)-propionic acid ethyl ester

There total 3 articles about (E)-2-(2-ethylbenzyl)-3-oxo-3-(4-phenylcyclohexyl)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400902-33-1
(E)-3-oxo-3-(4-phenylcyclohexyl)-propionic acid ethyl ester

: 57825-29-3
1-(bromomethyl)-2-ethylbenzene

: 1400902-37-5
(E)-2-(2-ethylbenzyl)-3-oxo-3-(4-phenylcyclohexyl)-propionic acid ethyl ester

Guidance literature:: (E)-3-oxo-3-(4-phenylcyclohexyl)-propionic acid ethyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 1h;

1-(bromomethyl)-2-ethylbenzene; In tetrahydrofuran; mineral oil; for 2h; Reflux;

Reference yield:

: 95233-37-7,49708-81-8,1346600-43-8
(+/-)-trans-4-(4-chlorophenyl)cyclohexane carboxylic acid

: 1400902-37-5
(E)-2-(2-ethylbenzyl)-3-oxo-3-(4-phenylcyclohexyl)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 96 h

1.2: 16 h / 20 °C

1.3: 0.25 h

2.1: dmap / dichloromethane / 0.17 h / 20 °C / Molecular sieve

2.2: 1.5 h / 20 °C

2.3: 1.5 h / Reflux

3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C

3.2: 2 h / Reflux

With dmap; hydrogen; sodium hydride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; mineral oil;

Reference yield:

: 1466-73-5
trans-4-phenylcyclohexanecarboxylic acid

: 1400902-37-5
(E)-2-(2-ethylbenzyl)-3-oxo-3-(4-phenylcyclohexyl)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap / dichloromethane / 0.17 h / 20 °C / Molecular sieve

1.2: 1.5 h / 20 °C

1.3: 1.5 h / Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C

2.2: 2 h / Reflux

With dmap; sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil;