(S)-3-(diphenylphosphoryl)-2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-1-methyl-1H-indole

Base Information

• Chemical Name: (S)-3-(diphenylphosphoryl)-2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-1-methyl-1H-indole
• CAS No.: 1260222-92-1
• Molecular Formula: C₂₇H₂₇N₂O₂P
• Molecular Weight: 442.497

Synonyms:(S)-3-(diphenylphosphoryl)-2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-1-methyl-1H-indole

Chemical Property of (S)-3-(diphenylphosphoryl)-2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-1-methyl-1H-indole

Chemical Property:

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Technology Process of (S)-3-(diphenylphosphoryl)-2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-1-methyl-1H-indole

There total 2 articles about (S)-3-(diphenylphosphoryl)-2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-1-methyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(S)-2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-1-methyl-1H-indole (1260222-82-9) + Diphenylphosphinic chloride (1499-21-4) → (S)-3-(diphenylphosphoryl)-2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-1-methyl-1H-indole (1260222-92-1)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1016/j.tetasy.2010.08.008

Reference yield: 77.0%

(S)-2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-1-methyl-1H-indole (1260222-82-9) + Diphenylphosphine oxide (4559-70-0) → (S)-3-(diphenylphosphoryl)-2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-1-methyl-1H-indole (1260222-92-1)

Guidance literature:

With triphenylphosphine; copper(l) chloride; In acetonitrile; at 50 ℃; for 24h; stereoselective reaction; Inert atmosphere;

DOI:10.1039/c4cc01815j

Reference yield: 71.0%

(S)-3-(diphenylphosphoryl)-2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-1-methyl-1H-indole (1260222-92-1) → (S)-3-(diphenylphosphino)-2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-1-methyl-1H-indole (1260222-64-7)

Guidance literature:

With trichlorosilane; triethylamine; In m-xylene; at 0 - 90 ℃;

DOI:10.1016/j.tetasy.2010.08.008

upstream raw materials:

(S)-2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-1-methyl-1H-indole

Diphenylphosphinic chloride

Diphenylphosphine oxide

Downstream raw materials:

(S)-3-(diphenylphosphino)-2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-1-methyl-1H-indole

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