(S)-2-{4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-1-hydroxymethyl-ethyl]-benzoylamino}-pentanedioic acid di-tert-butyl ester

Base Information

• Chemical Name: (S)-2-{4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-1-hydroxymethyl-ethyl]-benzoylamino}-pentanedioic acid di-tert-butyl ester
• CAS No.: 199458-37-2
• Molecular Formula: C₃₁H₄₀N₄O₇
• Molecular Weight: 580.681

Synonyms:(S)-2-{4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-1-hydroxymethyl-ethyl]-benzoylamino}-pentanedioic acid di-tert-butyl ester

Chemical Property of (S)-2-{4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-1-hydroxymethyl-ethyl]-benzoylamino}-pentanedioic acid di-tert-butyl ester

Chemical Property:

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Technology Process of (S)-2-{4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-1-hydroxymethyl-ethyl]-benzoylamino}-pentanedioic acid di-tert-butyl ester

There total 1 articles about (S)-2-{4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-1-hydroxymethyl-ethyl]-benzoylamino}-pentanedioic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

(S)-2-{4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-1-formyl-ethyl]-benzoylamino}-pentanedioic acid di-tert-butyl ester (145298-15-3) → (S)-2-{4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-1-hydroxymethyl-ethyl]-benzoylamino}-pentanedioic acid di-tert-butyl ester (199458-37-2)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃; for 0.166667h;

DOI:10.1016/S0968-0896(97)00121-1

Reference yield: 89.0%

2-Bromoacetyl bromide (598-21-0) + (S)-2-{4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-1-hydroxymethyl-ethyl]-benzoylamino}-pentanedioic acid di-tert-butyl ester (199458-37-2) → (S)-2-{4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-1-(2-bromo-acetoxymethyl)-ethyl]-benzoylamino}-pentanedioic acid di-tert-butyl ester

Guidance literature:

In dichloromethane; at 0 ℃; for 0.166667h;

DOI:10.1016/S0968-0896(97)00121-1

Reference yield: 80.0%

trifluoroacetic acid (76-05-1) + (S)-2-{4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-1-hydroxymethyl-ethyl]-benzoylamino}-pentanedioic acid di-tert-butyl ester (199458-37-2) → (S)-2-{4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-1-hydroxymethyl-ethyl]-benzoylamino}-pentanedioic acid; compound with trifluoro-acetic acid

Guidance literature:

In chloroform; at 0 - 25 ℃; for 14h;

DOI:10.1016/S0968-0896(97)00121-1

upstream raw materials:

(S)-2-{4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-1-formyl-ethyl]-benzoylamino}-pentanedioic acid di-tert-butyl ester

Downstream raw materials:

(S)-2-(4-{2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-1-[8-(tert-butyl-dimethyl-silanyloxy)-octanoyloxymethyl]-ethyl}-benzoylamino)-pentanedioic acid di-tert-butyl ester

(S)-2-{4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-1-methanesulfonyloxymethyl-ethyl]-benzoylamino}-pentanedioic acid di-tert-butyl ester

(S)-2-{4-[1-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-vinyl]-benzoylamino}-pentanedioic acid di-tert-butyl ester

(S)-2-{4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-1-bromo-1-bromomethyl-ethyl]-benzoylamino}-pentanedioic acid di-tert-butyl ester

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