1-(p-tolylsulfonyl)-5,6-dimethoxy-1,2,3,8a-tetrahydrocyclopentisoquinolin-7(8H)-one oxime

Base Information

• Chemical Name: 1-(p-tolylsulfonyl)-5,6-dimethoxy-1,2,3,8a-tetrahydrocyclopentisoquinolin-7(8H)-one oxime
• CAS No.: 105400-93-9
• Molecular Formula: C₂₀H₂₂N₂O₅S
• Molecular Weight: 402.471
• Mol file: 105400-93-9.mol

Synonyms:1-(p-tolylsulfonyl)-5,6-dimethoxy-1,2,3,8a-tetrahydrocyclopentisoquinolin-7(8H)-one oxime

Chemical Property of 1-(p-tolylsulfonyl)-5,6-dimethoxy-1,2,3,8a-tetrahydrocyclopentisoquinolin-7(8H)-one oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(p-tolylsulfonyl)-5,6-dimethoxy-1,2,3,8a-tetrahydrocyclopentisoquinolin-7(8H)-one oxime

There total 4 articles about 1-(p-tolylsulfonyl)-5,6-dimethoxy-1,2,3,8a-tetrahydrocyclopentisoquinolin-7(8H)-one oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(p-tolylsulfonyl)-5,6-dimethoxy-1,2,3,8a-tetrahydrocyclopentisoquinolin-7(8H)-one (105400-86-0) → 1-(p-tolylsulfonyl)-5,6-dimethoxy-1,2,3,8a-tetrahydrocyclopentisoquinolin-7(8H)-one oxime (105400-93-9)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; In ethanol; for 0.5h; Heating;

DOI:10.1021/jo00380a024

Reference yield:

6,7-dimethoxy-3,4-dihydro-isoquinoline (3382-18-1) → 1-(p-tolylsulfonyl)-5,6-dimethoxy-1,2,3,8a-tetrahydrocyclopentisoquinolin-7(8H)-one oxime (105400-93-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / 1 h / Heating

2: 66 percent / polyphosphoric acid / 1 h / Heating

3: 94 percent / pyridine / 1 h / 25 °C

4: 100 percent / hydroxylamine hydrochloride, pyridine / ethanol / 0.5 h / Heating

With pyridine; PPA; hydroxylamine hydrochloride; In ethanol;

DOI:10.1021/jo00380a024

Reference yield:

5,6-dimethoxy-1,2,3,8a-tetrahydrocyclopentisoquinolin-7(8H)-one (5868-19-9) → 1-(p-tolylsulfonyl)-5,6-dimethoxy-1,2,3,8a-tetrahydrocyclopentisoquinolin-7(8H)-one oxime (105400-93-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / pyridine / 1 h / 25 °C

2: 100 percent / hydroxylamine hydrochloride, pyridine / ethanol / 0.5 h / Heating

With pyridine; hydroxylamine hydrochloride; In ethanol;

DOI:10.1021/jo00380a024

upstream raw materials:

1-(p-tolylsulfonyl)-5,6-dimethoxy-1,2,3,8a-tetrahydrocyclopentisoquinolin-7(8H)-one

6,7-dimethoxy-3,4-dihydro-isoquinoline

5,6-dimethoxy-1,2,3,8a-tetrahydrocyclopentisoquinolin-7(8H)-one

2‐(6,7‐dimethoxy‐1,2,3,4‐tetrahydroisoquinolin‐1‐yl)acetic acid

Downstream raw materials:

1-(p-tolylsulfonyl)-5,6-dimethoxy-1,2,3,8a-tetrahydrocyclopentisoquinolin-7(8H)-one O-(p-tolylsulfonyl)oxime