anti-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite)

Base Information

• Chemical Name: anti-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite)
• CAS No.: 557789-96-5
• Molecular Formula: C₅₀H₅₈N₅O₁₀P
• Molecular Weight: 920.012

Synonyms:anti-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite)

Chemical Property of anti-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite)

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Technology Process of anti-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite)

There total 8 articles about anti-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.5%

anti-N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)-cytidine (112317-72-3) + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → anti-N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite) (557789-96-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4.5h;

DOI:10.1002/hlca.200790034

Reference yield:

anti-N4-benzoyl-2'-O-(tetrahydrofuran-2-yl)cytidine (87865-84-7) → anti-N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite) (557789-96-5)

Guidance literature:

Multi-step reaction with 2 steps

1: iPr₂EtN / pyridine

2: 58.5 percent / iPr₂EtN / CH₂Cl₂ / 4.5 h / 20 °C

With N-ethyl-N,N-diisopropylamine; In pyridine; dichloromethane;

DOI:10.1002/hlca.200790034

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → anti-N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite) (557789-96-5)

Guidance literature:

Multi-step reaction with 2 steps

1: iPr₂EtN / pyridine

2: 58.5 percent / iPr₂EtN / CH₂Cl₂ / 4.5 h / 20 °C

With N-ethyl-N,N-diisopropylamine; In pyridine; dichloromethane;

DOI:10.1002/hlca.200790034

upstream raw materials:

anti-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)-cytidine

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

anti-N⁴-benzoyl-2'-O-(tetrahydrofuran-2-yl)cytidine

4,4'-dimethoxytrityl chloride

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