2-(3-{[2,2-Difluoro-2-(4-fluoro naphthyl)ethyl]amino}-6-chloro-2-fluorophenyl)acetic acid

Base Information

Chemical Name:2-(3-{[2,2-Difluoro-2-(4-fluoro naphthyl)ethyl]amino}-6-chloro-2-fluorophenyl)acetic acid
CAS No.:409081-93-2
Molecular Formula:C₂₀H₁₄ClF₄NO₂
Molecular Weight:411.783
Hs Code.:

Synonyms:2-(3-{[2,2-Difluoro-2-(4-fluoro naphthyl)ethyl]amino}-6-chloro-2-fluorophenyl)acetic acid

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Chemical Property of 2-(3-{[2,2-Difluoro-2-(4-fluoro naphthyl)ethyl]amino}-6-chloro-2-fluorophenyl)acetic acid

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Technology Process of 2-(3-{[2,2-Difluoro-2-(4-fluoro naphthyl)ethyl]amino}-6-chloro-2-fluorophenyl)acetic acid

There total 1 articles about 2-(3-{[2,2-Difluoro-2-(4-fluoro naphthyl)ethyl]amino}-6-chloro-2-fluorophenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 2-(3-{[2,2-Difluoro-2-(4-fluoronaphthyl)ethyl]amino]-6-chloro-2-fluorophenyl)ethanal

: 409081-93-2
2-(3-{[2,2-Difluoro-2-(4-fluoro naphthyl)ethyl]amino}-6-chloro-2-fluorophenyl)acetic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; In water; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2007.09.013

Reference yield: 49.0%

: 409081-93-2
2-(3-{[2,2-Difluoro-2-(4-fluoro naphthyl)ethyl]amino}-6-chloro-2-fluorophenyl)acetic acid

: 187163-72-0
2-tert-butoxycarbonylamino-5-aminomethyl-6-methyl-pyridine

: 409081-95-4
2-(3-{[2,2-difluoro-2-(4-fluoronaphthyl)ethyl]amino}-6-chloro-2-fluorophenyl)-N-({6-[(tert-butoxy)carbonylamino]-2-methyl(3-pyridyl)}methyl)acetamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

Reference yield:

: ({[(tert-butoxycarbonyl)amino-(tert-butoxycarbonyl)iminomethyl]aminooxy}ethyl)amine hydrochloride

: 409081-93-2
2-(3-{[2,2-Difluoro-2-(4-fluoro naphthyl)ethyl]amino}-6-chloro-2-fluorophenyl)acetic acid

: C₃₃H₃₈ClF₄N₅O₆

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.09.013