N-Tert-butyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-A]pyrazine-3-carboxamide

Base Information

Chemical Name:N-Tert-butyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-A]pyrazine-3-carboxamide
CAS No.:723286-71-3
Molecular Formula:C₁₀H₁₇N₅O
Molecular Weight:223.278
Hs Code.:
DSSTox Substance ID:DTXSID60693876
Wikidata:Q82622854
Mol file:723286-71-3.mol

Synonyms:723286-71-3;N-TERT-BUTYL-5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-3-CARBOXAMIDE;1,2,4-Triazolo[4,3-a]pyrazine-3-carboxamide,N-(1,1-dimethylethyl)-5,6,7,8-tetrahydro-;SCHEMBL5935846;DTXSID60693876;NVHFJZVJZIDGPG-UHFFFAOYSA-N;AKOS015904413;A837488;N-(tert-Butyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine-3-carboxamide;N-tert-Butyl-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine-3-carboxamide

Suppliers and Price of N-Tert-butyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-A]pyrazine-3-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of N-Tert-butyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-A]pyrazine-3-carboxamide

Chemical Property:

PSA：71.84000
LogP:0.62930
XLogP3:-0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:223.14331018
Heavy Atom Count:16
Complexity:275

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)NC(=O)C1=NN=C2N1CCNC2

Technology Process of N-Tert-butyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-A]pyrazine-3-carboxamide

There total 3 articles about N-Tert-butyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-A]pyrazine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 723286-70-2
N-tert-butyl-[1,2,4]triazolo[4,3-a]pyrazine-3-carboxamide

: 723286-71-3
N-tert-butyl-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine-3-carboxamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 18h;
DOI:10.1016/j.bmcl.2007.03.098

Reference yield:

: 723286-66-6
ethyl oxo-(2-pyrazin-2-yl-hydrazino)acetate

: 723286-71-3
N-tert-butyl-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 31 percent / PTSA / toluene / 6 h / Heating

2: H₂ / Pd/C / ethanol / 18 h / 20 °C

With hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In ethanol; toluene;
DOI:10.1016/j.bmcl.2007.03.098

Reference yield:

: 723286-67-7
ethyl [1,2,4]triazolo[4,3-a]pyrazine-3-carboxylate

: 723286-71-3
N-tert-butyl-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethanol / 18 h / 20 °C

With hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1016/j.bmcl.2007.03.098