(E)-S-4-cyclohexylbut-3-en-2-yl 2-methoxyphenyl(methyl)carbamothioate

Base Information

• Chemical Name: (E)-S-4-cyclohexylbut-3-en-2-yl 2-methoxyphenyl(methyl)carbamothioate
• CAS No.: 1415351-94-8
• Molecular Formula: C₁₉H₂₇NO₂S
• Molecular Weight: 333.495
• Mol file: 1415351-94-8.mol

Synonyms:(E)-S-4-cyclohexylbut-3-en-2-yl 2-methoxyphenyl(methyl)carbamothioate

Chemical Property of (E)-S-4-cyclohexylbut-3-en-2-yl 2-methoxyphenyl(methyl)carbamothioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-S-4-cyclohexylbut-3-en-2-yl 2-methoxyphenyl(methyl)carbamothioate

There total 2 articles about (E)-S-4-cyclohexylbut-3-en-2-yl 2-methoxyphenyl(methyl)carbamothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(E)-S-4-cyclohexylbut-3-en-2-yl 1H-imidazole-1-carbothioate (1415351-98-2) + 2-methoxy-N-methylaniline (10541-78-3) → (E)-S-4-cyclohexylbut-3-en-2-yl 2-methoxyphenyl(methyl)carbamothioate (1415351-94-8)

Guidance literature:

With benzotriazol-1-ol; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere; Reflux;

DOI:10.1039/c4cc02596b

Reference yield:

1-cyclohexyl-but-2-en-1-ol (18736-82-8) → (E)-S-4-cyclohexylbut-3-en-2-yl 2-methoxyphenyl(methyl)carbamothioate (1415351-94-8)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap / 1,2-dichloro-ethane / 26 h / 40 °C / Inert atmosphere

2: benzotriazol-1-ol / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere; Reflux

With dmap; benzotriazol-1-ol; In tetrahydrofuran; 1,2-dichloro-ethane;

DOI:10.1039/c4cc02596b

Reference yield: 99.0%

(E)-S-4-cyclohexylbut-3-en-2-yl 2-methoxyphenyl(methyl)carbamothioate (1415351-94-8) → (E)-S-4-cyclohexyl-2-(2-methoxyphenyl)but-3-en-2-yl methylcarbamothioate (1613417-23-4)

Guidance literature:

(E)-S-4-cyclohexylbut-3-en-2-yl 2-methoxyphenyl(methyl)carbamothioate; With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; at -78 - -60 ℃; Inert atmosphere;

With propionic acid; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1039/c4cc02596b

upstream raw materials:

(E)-S-4-cyclohexylbut-3-en-2-yl 1H-imidazole-1-carbothioate

2-methoxy-N-methylaniline

1-cyclohexyl-but-2-en-1-ol

Downstream raw materials:

(S)-(E)-S-4-cyclohexyl-2-(2-methoxyphenyl)but-3-en-2-yl methylcarbamothioate

(E)-allyl(4-cyclohexyl-2-(2-methoxyphenyl)but-3-en-2-yl)sulfane

(S)-(E)-allyl(4-cyclohexyl-2-(2-methoxyphenyl)but-3-en-2-yl)sulfane

(E)-4-cyclohexyl-2-(2-methoxyphenyl)but-3-ene-2-thiol