N-(6-Aminohexyl)maleimide hydrochloride salt

Base Information

• Chemical Name: N-(6-Aminohexyl)maleimide hydrochloride salt
• CAS No.: 75238-09-4
• Molecular Formula: C₁₀H₁₆N₂O₂*ClH
• Molecular Weight: 232.71
• Mol file: 75238-09-4.mol

Synonyms:1H-Pyrrole-2,5-dione,1-(6-aminohexyl)-, monohydrochloride (9CI);N-(6-Aminohexyl)maleimidehydrochloride;

Chemical Property of N-(6-Aminohexyl)maleimide hydrochloride salt

Chemical Property:

• Boiling Point: 365.7 °C at 760 mmHg
• Flash Point: 175 °C
• PSA: 63.40000
• LogP: 1.87070

Purity/Quality:

97% ^*data from raw suppliers

1-(6-Aminohexyl)-1H-pyrrole-2,5-dionehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(6-Aminohexyl)maleimide hydrochloride salt

There total 3 articles about N-(6-Aminohexyl)maleimide hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

tert-butyl (6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexyl)carbamate (124529-64-2) → 1-(6-aminohexyl)-1H-pyrrole-2,5-dione hydrochloride (75238-09-4)

Guidance literature:

tert-butyl (6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexyl)carbamate; With trifluoroacetic acid; In chloroform; at 20 ℃; for 2h;

With hydrogenchloride; In diethyl ether; water;

DOI:10.1002/ejoc.201900280

Reference yield:

4N-HCl + hexylcarbamic acid tert-butyl ester (207558-25-6) → 1-(6-aminohexyl)-1H-pyrrole-2,5-dione hydrochloride (75238-09-4)

Guidance literature:

In 1,4-dioxane; diethyl ether;

Reference yield:

6-amino-1-hexanol (4048-33-3) → 1-(6-aminohexyl)-1H-pyrrole-2,5-dione hydrochloride (75238-09-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hydroxide / water / 0 °C

1.2: 4 h / 0 - 20 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 20 °C

3.1: trifluoroacetic acid / chloroform / 2 h / 20 °C

With di-isopropyl azodicarboxylate; triphenylphosphine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; chloroform; water;

DOI:10.1002/ejoc.201900280

upstream raw materials:

hexylcarbamic acid tert-butyl ester

tert-butyl (6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexyl)carbamate

6-amino-1-hexanol

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